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Assay Detail

CHEMBL2216696

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of PCP after 1 hr by fluorescence assay
ChEMBL ↗
63
Total Activities
63
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Bone morphogenetic protein 1 (CHEMBL3898) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Design and synthesis of procollagen C-proteinase inhibitors.
Turtle E, Chow N, Yang C, Sosa S, Bauer U, Brenner M, Solow-Cordero D, Ho WB.
Bioorg Med Chem Lett (2012) 22 : 7397 -7401
PubMed 23134659 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 63 5.48 8.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2204087 — — 1 8.00
CHEMBL2204088 — — 1 7.52
CHEMBL2204817 — — 1 7.38
CHEMBL2204089 — — 1 7.22
CHEMBL2204085 — — 1 7.14
CHEMBL2204802 — — 1 7.10
CHEMBL2204815 — — 1 7.03
CHEMBL2204807 — — 1 6.54
CHEMBL2204086 — — 1 6.52
CHEMBL2204816 — — 1 6.46
CHEMBL2204083 — — 1 6.42
CHEMBL2204803 — — 1 6.40
CHEMBL2204805 — — 1 6.39
CHEMBL2204806 — — 1 6.33
CHEMBL2204084 — — 1 6.11
CHEMBL2204820 — — 1 6.05
CHEMBL2204836 — — 1 6.00
CHEMBL2204800 — — 1 6.00
CHEMBL2204833 — — 1 6.00
CHEMBL2204835 — — 1 5.77
CHEMBL2204832 — — 1 5.77
CHEMBL2204799 — — 1 5.66
CHEMBL2204837 — — 1 5.64
CHEMBL2204846 — — 1 5.55
CHEMBL2204818 — — 1 5.52
CHEMBL2204819 — — 1 5.35
CHEMBL2204810 — — 1 5.33
CHEMBL2204823 — — 1 5.31
CHEMBL2204091 — — 1 5.17
CHEMBL2204804 — — 1 5.15

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2204087 — IC50 = 10.0 nM 8.00
CHEMBL2204088 — IC50 = 30.0 nM 7.52
CHEMBL2204817 — IC50 = 42.0 nM 7.38
CHEMBL2204089 — IC50 = 60.0 nM 7.22
CHEMBL2204085 — IC50 = 73.0 nM 7.14
CHEMBL2204802 — IC50 = 80.0 nM 7.10
CHEMBL2204815 — IC50 = 93.0 nM 7.03
CHEMBL2204807 — IC50 = 290.0 nM 6.54
CHEMBL2204086 — IC50 = 300.0 nM 6.52
CHEMBL2204816 — IC50 = 350.0 nM 6.46
CHEMBL2204083 — IC50 = 380.0 nM 6.42
CHEMBL2204803 — IC50 = 400.0 nM 6.40
CHEMBL2204805 — IC50 = 410.0 nM 6.39
CHEMBL2204806 — IC50 = 470.0 nM 6.33
CHEMBL2204084 — IC50 = 780.0 nM 6.11
CHEMBL2204820 — IC50 = 900.0 nM 6.05
CHEMBL2204836 — IC50 = 1000.0 nM 6.00
CHEMBL2204800 — IC50 = 1000.0 nM 6.00
CHEMBL2204833 — IC50 = 1000.0 nM 6.00
CHEMBL2204835 — IC50 = 1700.0 nM 5.77
CHEMBL2204832 — IC50 = 1700.0 nM 5.77
CHEMBL2204799 — IC50 = 2200.0 nM 5.66
CHEMBL2204837 — IC50 = 2300.0 nM 5.64
CHEMBL2204846 — IC50 = 2800.0 nM 5.55
CHEMBL2204818 — IC50 = 3000.0 nM 5.52
CHEMBL2204819 — IC50 = 4500.0 nM 5.35
CHEMBL2204810 — IC50 = 4700.0 nM 5.33
CHEMBL2204823 — IC50 = 4900.0 nM 5.31
CHEMBL2204091 — IC50 = 6700.0 nM 5.17
CHEMBL2204804 — IC50 = 7100.0 nM 5.15
CHEMBL2204834 — IC50 = 8100.0 nM 5.09
CHEMBL2204808 — IC50 = 9100.0 nM 5.04
CHEMBL2204814 — IC50 = 9400.0 nM 5.03
CHEMBL2204845 — IC50 = 10000.0 nM 5.00
CHEMBL2204822 — IC50 = 10000.0 nM 5.00
CHEMBL2204839 — IC50 = 11000.0 nM 4.96
CHEMBL2204811 — IC50 = 13000.0 nM 4.89
CHEMBL2204813 — IC50 = 14000.0 nM 4.85
CHEMBL82868 — IC50 = 16000.0 nM 4.80
CHEMBL2204809 — IC50 = 17000.0 nM 4.77
CHEMBL82331 — IC50 = 18000.0 nM 4.75
CHEMBL2204828 — IC50 = 18000.0 nM 4.75
CHEMBL312218 — IC50 = 19000.0 nM 4.72
CHEMBL2204840 — IC50 = 23000.0 nM 4.64
CHEMBL2204821 — IC50 = 28000.0 nM 4.55
CHEMBL82783 — IC50 = 29000.0 nM 4.54
CHEMBL2204825 — IC50 = 34000.0 nM 4.47
CHEMBL2204841 — IC50 = 40000.0 nM 4.40
CHEMBL2203295 — IC50 = 42000.0 nM 4.38
CHEMBL2204844 — IC50 = 42000.0 nM 4.38