Assay Detail
Binding
CHEMBL2216958
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to human cyclophilin A by fluorescence polarization assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Peptidyl-prolyl cis-trans isomerase A (CHEMBL1949) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Ranking high affinity ligands of low solubility by NMR spectroscopy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 4 | 7.97 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL160 | CYCLOSPORINE | 4.0 | 1 | 8.00 |
| CHEMBL2216758 | — | — | 1 | 7.96 |
| CHEMBL2216757 | — | — | 1 | 7.96 |
| CHEMBL1651956 | ALISPORIVIR | 3.0 | 1 | 7.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL160 | CYCLOSPORINE | Kd | = | 10.0 | nM | 8.00 |
| CHEMBL2216758 | — | Kd | = | 11.0 | nM | 7.96 |
| CHEMBL2216757 | — | Kd | = | 11.0 | nM | 7.96 |
| CHEMBL1651956 | ALISPORIVIR | Kd | = | 11.0 | nM | 7.96 |