Assay Detail
Binding
CHEMBL2217014
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of carnitine palmitoyltransferase in rat liver mitochondria assessed as conversion of [14C]palmitic acid to [14C]palmitoylcarnitine by radiometric assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Liver |
| Subcellular | Mitochondria |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Carnitine palmitoyltransferase (CPT) modulators: a medicinal chemistry perspective on 35 years of research.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.13 | 6.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2216784 | — | — | 1 | 6.92 |
| CHEMBL2216785 | — | — | 1 | 6.89 |
| CHEMBL307495 | — | — | 1 | 6.16 |
| CHEMBL308869 | — | — | 1 | 6.10 |
| CHEMBL1231506 | TEGLICAR | 2.0 | 1 | 5.96 |
| CHEMBL114113 | — | — | 1 | 4.76 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2216784 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL2216785 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL307495 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL308869 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL1231506 | TEGLICAR | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL114113 | — | IC50 | = | 17400.0 | nM | 4.76 |