Assay Detail
Binding
CHEMBL2217262
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Inhibition of PI3Kdelta
84
Total Activities
84
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (CHEMBL3130) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
PI3Kδ and PI3Kγ as targets for autoimmune and inflammatory diseases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 71 | 7.89 | 9.52 |
| Ki | 13 | 8.56 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2216895 | — | — | 1 | 9.70 |
| CHEMBL2216876 | — | — | 1 | 9.52 |
| CHEMBL2216902 | — | — | 1 | 9.34 |
| CHEMBL1213118 | — | — | 1 | 9.30 |
| CHEMBL2216903 | — | — | 1 | 9.24 |
| CHEMBL1213084 | — | — | 1 | 9.15 |
| CHEMBL1213117 | — | — | 1 | 9.00 |
| CHEMBL2216891 | — | — | 1 | 8.98 |
| CHEMBL2216892 | — | — | 1 | 8.65 |
| CHEMBL2216882 | — | — | 1 | 8.56 |
| CHEMBL2216890 | — | — | 1 | 8.54 |
| CHEMBL2216844 | — | — | 1 | 8.52 |
| CHEMBL2216848 | — | — | 1 | 8.52 |
| CHEMBL2216850 | — | — | 1 | 8.52 |
| CHEMBL521851 | PICTILISIB | 2.0 | 1 | 8.52 |
| CHEMBL2152768 | — | — | 1 | 8.46 |
| CHEMBL2216881 | — | — | 1 | 8.44 |
| CHEMBL2216862 | — | — | 1 | 8.40 |
| CHEMBL586702 | ZSTK-474 | 2.0 | 1 | 8.34 |
| CHEMBL2216901 | — | — | 1 | 8.31 |
| CHEMBL2216893 | — | — | 1 | 8.30 |
| CHEMBL2216872 | — | — | 1 | 8.23 |
| CHEMBL2216885 | — | — | 1 | 8.22 |
| CHEMBL2216855 | — | — | 1 | 8.22 |
| CHEMBL1213116 | — | — | 1 | 8.15 |
| CHEMBL2216871 | — | — | 1 | 8.15 |
| CHEMBL2216870 | IDELALISIB | 4.0 | 1 | 8.05 |
| CHEMBL428496 | WORTMANNIN | — | 1 | 8.05 |
| CHEMBL1213085 | — | — | 1 | 8.05 |
| CHEMBL2216849 | — | — | 1 | 8.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2216895 | — | Ki | = | 0.2 | nM | 9.70 |
| CHEMBL2216876 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL2216902 | — | Ki | = | 0.46 | nM | 9.34 |
| CHEMBL1213118 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL2216903 | — | Ki | = | 0.576 | nM | 9.24 |
| CHEMBL1213084 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL1213117 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL2216891 | — | Ki | = | 1.05 | nM | 8.98 |
| CHEMBL2216892 | — | Ki | = | 2.26 | nM | 8.65 |
| CHEMBL2216882 | — | IC50 | = | 2.74 | nM | 8.56 |
| CHEMBL2216890 | — | Ki | = | 2.85 | nM | 8.54 |
| CHEMBL2216850 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL521851 | PICTILISIB | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL2216848 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL2216844 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL2152768 | — | IC50 | = | 3.43 | nM | 8.46 |
| CHEMBL2216881 | — | IC50 | = | 3.6 | nM | 8.44 |
| CHEMBL2216862 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL586702 | ZSTK-474 | IC50 | = | 4.6 | nM | 8.34 |
| CHEMBL2216901 | — | Ki | = | 4.9 | nM | 8.31 |
| CHEMBL2216893 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL2216872 | — | IC50 | = | 5.9 | nM | 8.23 |
| CHEMBL2216885 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL2216855 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL2216871 | — | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL1213116 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL2216870 | IDELALISIB | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL428496 | WORTMANNIN | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL1213085 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL2216849 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL1241767 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL2216756 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL2216873 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL2216833 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL2071341 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL2152252 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL2216856 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL2216880 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL2216857 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL2152253 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL1213169 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL1213119 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL2216884 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL2216874 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL1213168 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL2216847 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL2216894 | — | IC50 | = | 105.9 | nM | 6.97 |
| CHEMBL2216832 | — | IC50 | = | 139.0 | nM | 6.86 |
| CHEMBL2216845 | — | IC50 | = | 197.0 | nM | 6.71 |
| CHEMBL2216858 | — | IC50 | = | 260.0 | nM | 6.58 |