Assay Detail
Binding
CHEMBL2217271
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Inhibition of PI3Kgamma in presence of 10 uM ATP
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (CHEMBL3267) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
PI3Kδ and PI3Kγ as targets for autoimmune and inflammatory diseases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.89 | 7.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1241857 | — | — | 1 | 7.75 |
| CHEMBL573339 | PI-103 | — | 1 | 6.82 |
| CHEMBL1213083 | — | — | 1 | 4.77 |
| CHEMBL1213082 | — | — | 1 | 4.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1241857 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL573339 | PI-103 | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL1213083 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL1213082 | — | IC50 | = | 61000.0 | nM | 4.21 |