Assay Detail
Binding
CHEMBL2217317
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PI3Kdelta in human whole blood assessed as inhibition of CD69 production in B lymphocyte by immunoassay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Tissue | Blood |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (CHEMBL3130) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
PI3Kδ and PI3Kγ as targets for autoimmune and inflammatory diseases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.94 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2216902 | — | — | 1 | 8.52 |
| CHEMBL2216903 | — | — | 1 | 8.28 |
| CHEMBL2216901 | — | — | 1 | 7.77 |
| CHEMBL2216882 | — | — | 1 | 7.75 |
| CHEMBL2152768 | — | — | 1 | 7.39 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2216902 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL2216903 | — | IC50 | = | 5.2 | nM | 8.28 |
| CHEMBL2216901 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL2216882 | — | IC50 | = | 17.8 | nM | 7.75 |
| CHEMBL2152768 | — | IC50 | = | 41.0 | nM | 7.39 |