Assay Detail
Binding
CHEMBL2317017
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Inhibition of wild type HIV1 integrase 3'-processing activity using 5'-end 32P-labeled linear oligonucleotide as substrate preincubated for 30 mins
38
Total Activities
38
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Human immunodeficiency virus type 1 integrase (CHEMBL3471) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Discovery of novel inhibitors of LEDGF/p75-IN protein-protein interactions.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 38 | 4.24 | 4.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2311867 | — | — | 1 | 4.77 |
| CHEMBL2311873 | — | — | 1 | 4.54 |
| CHEMBL2094513 | — | — | 1 | 4.16 |
| CHEMBL2311887 | — | — | 1 | 4.11 |
| CHEMBL2311881 | — | — | 1 | 4.05 |
| CHEMBL2311882 | — | — | 1 | 4.05 |
| CHEMBL2311878 | — | — | 1 | 4.00 |
| CHEMBL2311897 | — | — | 1 | - |
| CHEMBL2311912 | — | — | 1 | - |
| CHEMBL2311911 | — | — | 1 | - |
| CHEMBL2311910 | — | — | 1 | - |
| CHEMBL1976649 | — | — | 1 | - |
| CHEMBL2311908 | — | — | 1 | - |
| CHEMBL2311906 | — | — | 1 | - |
| CHEMBL2311904 | — | — | 1 | - |
| CHEMBL2311903 | — | — | 1 | - |
| CHEMBL2311902 | — | — | 1 | - |
| CHEMBL2311898 | — | — | 1 | - |
| CHEMBL1597979 | — | — | 1 | - |
| CHEMBL2311866 | — | — | 1 | - |
| CHEMBL199592 | — | — | 1 | - |
| CHEMBL200144 | — | — | 1 | - |
| CHEMBL569410 | — | — | 1 | - |
| CHEMBL2311868 | — | — | 1 | - |
| CHEMBL390195 | — | — | 1 | - |
| CHEMBL2311870 | — | — | 1 | - |
| CHEMBL2311872 | — | — | 1 | - |
| CHEMBL2311874 | — | — | 1 | - |
| CHEMBL2311877 | — | — | 1 | - |
| CHEMBL2094455 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2311867 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL2311873 | — | IC50 | = | 29000.0 | nM | 4.54 |
| CHEMBL2094513 | — | IC50 | = | 69000.0 | nM | 4.16 |
| CHEMBL2311887 | — | IC50 | = | 77000.0 | nM | 4.11 |
| CHEMBL2311881 | — | IC50 | = | 90000.0 | nM | 4.05 |
| CHEMBL2311882 | — | IC50 | = | 90000.0 | nM | 4.05 |
| CHEMBL2311878 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL2311908 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2311879 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2311906 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2311904 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2311903 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2311902 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2311898 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2311912 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2311896 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2311893 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2311891 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2311890 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2311889 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2311888 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2311885 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1976649 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2311910 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2311911 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2311897 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1597979 | — | IC50 | < | 100000.0 | nM | - |
| CHEMBL2311866 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL199592 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL200144 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL569410 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2311868 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL390195 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2311870 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2311872 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2311874 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2311877 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2094455 | — | IC50 | > | 100000.0 | nM | - |