Assay Detail
Binding
CHEMBL2317358
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Inhibition of human MAOA after 1 hr by luminescence assay
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis of (E)-8-(3-chlorostyryl)caffeine analogues leading to 9-deazaxanthine derivatives as dual A(2A) antagonists/MAO-B inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 5.88 | 7.91 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL8706 | CLORGILINE | 2.0 | 1 | 7.91 |
| CHEMBL2312981 | — | — | 1 | 6.14 |
| CHEMBL2313296 | — | — | 1 | 6.09 |
| CHEMBL2313294 | — | — | 1 | 5.91 |
| CHEMBL2312988 | — | — | 1 | 5.89 |
| CHEMBL2312989 | — | — | 1 | 5.79 |
| CHEMBL2313286 | — | — | 1 | 5.69 |
| CHEMBL2312975 | — | — | 1 | 5.54 |
| CHEMBL2313291 | — | — | 1 | 5.51 |
| CHEMBL2313295 | — | — | 1 | 5.25 |
| CHEMBL2313297 | — | — | 1 | 5.00 |
| CHEMBL2313285 | — | — | 1 | - |
| CHEMBL2313284 | — | — | 1 | - |
| CHEMBL2313279 | — | — | 1 | - |
| CHEMBL2313277 | — | — | 1 | - |
| CHEMBL2312987 | — | — | 1 | - |
| CHEMBL2313298 | — | — | 1 | - |
| CHEMBL2312976 | — | — | 1 | - |
| CHEMBL2313292 | — | — | 1 | - |
| CHEMBL2312977 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL8706 | CLORGILINE | IC50 | = | 12.4 | nM | 7.91 |
| CHEMBL2312981 | — | IC50 | = | 726.3 | nM | 6.14 |
| CHEMBL2313296 | — | IC50 | = | 812.3 | nM | 6.09 |
| CHEMBL2313294 | — | IC50 | = | 1237.0 | nM | 5.91 |
| CHEMBL2312988 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL2312989 | — | IC50 | = | 1632.0 | nM | 5.79 |
| CHEMBL2313286 | — | IC50 | = | 2022.0 | nM | 5.69 |
| CHEMBL2312975 | — | IC50 | = | 2870.0 | nM | 5.54 |
| CHEMBL2313291 | — | IC50 | = | 3110.0 | nM | 5.51 |
| CHEMBL2313295 | — | IC50 | = | 5690.0 | nM | 5.25 |
| CHEMBL2313297 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL2313285 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2313284 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2313279 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2313277 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2312987 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL2313298 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2312976 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2313292 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2312977 | — | IC50 | > | 10000.0 | nM | - |