Assay Detail
Binding
CHEMBL2317645
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human EAAT2 expressed in HEK293 cells by [3H]-D-Asp uptake assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Chemoenzymatic synthesis of new 2,4-syn-functionalized (S)-glutamate analogues and structure-activity relationship studies at ionotropic glutamate receptors and excitatory amino acid transporters.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 4.62 | 4.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2312682 | — | — | 1 | 4.62 |
| CHEMBL2312686 | — | — | 1 | - |
| CHEMBL2312685 | — | — | 1 | - |
| CHEMBL2312684 | — | — | 1 | - |
| CHEMBL2312683 | — | — | 1 | - |
| CHEMBL2312681 | — | — | 1 | - |
| CHEMBL2312403 | — | — | 1 | - |
| CHEMBL2312402 | — | — | 1 | - |
| CHEMBL2312400 | — | — | 1 | - |
| CHEMBL2312399 | — | — | 1 | - |
| CHEMBL2312397 | — | — | 1 | - |
| CHEMBL2312396 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2312682 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL2312686 | — | IC50 | > | 300000.0 | nM | - |
| CHEMBL2312685 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL2312684 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL2312683 | — | IC50 | = | 700000.0 | nM | - |
| CHEMBL2312681 | — | IC50 | = | 300000.0 | nM | - |
| CHEMBL2312403 | — | IC50 | = | 1000000.0 | nM | - |
| CHEMBL2312402 | — | IC50 | = | 300000.0 | nM | - |
| CHEMBL2312400 | — | IC50 | > | 300000.0 | nM | - |
| CHEMBL2312399 | — | IC50 | > | 300000.0 | nM | - |
| CHEMBL2312397 | — | IC50 | > | 300000.0 | nM | - |
| CHEMBL2312396 | — | IC50 | > | 300000.0 | nM | - |