Assay Detail
Functional
CHEMBL2317899
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Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HepG2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and anticancer activity of a novel series of 9-O-substituted berberine derivatives: a lipophilic substitute role.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.35 | 7.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2313433 | — | — | 1 | 7.10 |
| CHEMBL2313430 | — | — | 1 | 7.00 |
| CHEMBL2313429 | — | — | 1 | 7.00 |
| CHEMBL2313432 | — | — | 1 | 6.77 |
| CHEMBL2313428 | — | — | 1 | 6.01 |
| CHEMBL2313431 | — | — | 1 | 5.50 |
| CHEMBL12089 | BERBERINE CHLORIDE | 1.0 | 1 | 5.08 |
| CHEMBL1223099 | BERBERRUBINE CHLORIDE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2313433 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL2313430 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL2313429 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL2313432 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL2313428 | — | IC50 | = | 970.0 | nM | 6.01 |
| CHEMBL2313431 | — | IC50 | = | 3170.0 | nM | 5.50 |
| CHEMBL12089 | BERBERINE CHLORIDE | IC50 | = | 8320.0 | nM | 5.08 |
| CHEMBL1223099 | BERBERRUBINE CHLORIDE | IC50 | > | 50000.0 | nM | - |