Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL2318035

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiprotozoal activity against erythrocytic stages of Plasmodium falciparum K1 by [3H]hypoxanthine incorporation assay
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Plasmodium falciparum
Confidence 1 — Organism
Curated By Autocuration

Target

Plasmodium falciparum (CHEMBL364)
Type ORGANISM
Organism Plasmodium falciparum

Publication

Discovery and preliminary structure-activity relationship analysis of 1,14-sperminediphenylacetamides as potent and selective antimalarial lead compounds.
Liew LP, Kaiser M, Copp BR.
Bioorg Med Chem Lett (2013) 23 : 452 -454
PubMed 23265884 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 26 6.19 8.07

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2314244 1 8.07
CHEMBL2314235 1 7.72
CHEMBL211029 1 6.85
CHEMBL2314233 1 6.85
CHEMBL2314232 1 6.77
CHEMBL76 CHLOROQUINE 4.0 1 6.55
CHEMBL2314236 1 6.21
CHEMBL2314243 1 6.05
CHEMBL2314238 1 5.44
CHEMBL2314234 1 5.32
CHEMBL2314231 1 5.10
CHEMBL2314239 1 5.10
CHEMBL2314230 1 4.46
CHEMBL2314229 1 -
CHEMBL2314228 1 -
CHEMBL2314227 1 -
CHEMBL2314226 1 -
CHEMBL2314225 1 -
CHEMBL2314224 1 -
CHEMBL2311566 1 -
CHEMBL2314223 1 -
CHEMBL2314237 1 -
CHEMBL2314222 1 -
CHEMBL2314242 1 -
CHEMBL2314240 1 -
CHEMBL2314241 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2314244 IC50 = 8.6 nM 8.07
CHEMBL2314235 IC50 = 19.0 nM 7.72
CHEMBL211029 IC50 = 140.0 nM 6.85
CHEMBL2314233 IC50 = 140.0 nM 6.85
CHEMBL2314232 IC50 = 170.0 nM 6.77
CHEMBL76 CHLOROQUINE IC50 = 280.0 nM 6.55
CHEMBL2314236 IC50 = 610.0 nM 6.21
CHEMBL2314243 IC50 = 890.0 nM 6.05
CHEMBL2314238 IC50 = 3600.0 nM 5.44
CHEMBL2314234 IC50 = 4800.0 nM 5.32
CHEMBL2314231 IC50 = 8000.0 nM 5.10
CHEMBL2314239 IC50 = 7900.0 nM 5.10
CHEMBL2314230 IC50 = 35000.0 nM 4.46
CHEMBL2314229 IC50 > 14000.0 nM -
CHEMBL2314228 IC50 > 12000.0 nM -
CHEMBL2314227 IC50 > 9600.0 nM -
CHEMBL2314226 IC50 > 11000.0 nM -
CHEMBL2314225 IC50 > 9100.0 nM -
CHEMBL2314224 IC50 > 13000.0 nM -
CHEMBL2311566 IC50 > 6800.0 nM -
CHEMBL2314223 IC50 > 15000.0 nM -
CHEMBL2314237 IC50 > 8500.0 nM -
CHEMBL2314222 IC50 > 12000.0 nM -
CHEMBL2314242 IC50 > 9400.0 nM -
CHEMBL2314240 IC50 > 8900.0 nM -
CHEMBL2314241 IC50 > 10000.0 nM -