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Assay Detail

CHEMBL2318142

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of sheep dyn1 after 30 mins by malachite green GTPase assay in presence of GTP
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Ovis aries
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Development of second-generation indole-based dynamin GTPase inhibitors.
Gordon CP, Venn-Brown B, Robertson MJ, Young KA, Chau N, Mariana A, Whiting A, Chircop M, Robinson PJ, McCluskey A.
J Med Chem (2013) 56 : 46 -59
PubMed 23167654 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 29 5.32 6.25

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2312430 1 6.25
CHEMBL2312431 1 6.12
CHEMBL2312432 1 5.96
CHEMBL483059 1 5.89
CHEMBL2312428 1 5.64
CHEMBL2312412 1 5.58
CHEMBL2312411 1 5.54
CHEMBL2312415 1 5.36
CHEMBL2312414 1 5.32
CHEMBL2312427 1 5.28
CHEMBL2312426 1 5.11
CHEMBL2312433 1 5.01
CHEMBL2312429 1 5.01
CHEMBL522225 1 5.00
CHEMBL2312416 1 4.75
CHEMBL2312410 1 4.73
CHEMBL2312409 1 4.66
CHEMBL496230 1 4.50
CHEMBL2312424 1 -
CHEMBL2312423 1 -
CHEMBL2312422 1 -
CHEMBL2312421 1 -
CHEMBL2312420 1 -
CHEMBL2312419 1 -
CHEMBL2312418 1 -
CHEMBL2312417 1 -
CHEMBL2312425 1 -
CHEMBL482852 1 -
CHEMBL2312413 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2312430 IC50 = 560.0 nM 6.25
CHEMBL2312431 IC50 = 760.0 nM 6.12
CHEMBL2312432 IC50 = 1100.0 nM 5.96
CHEMBL483059 IC50 = 1300.0 nM 5.89
CHEMBL2312428 IC50 = 2300.0 nM 5.64
CHEMBL2312412 IC50 = 2600.0 nM 5.58
CHEMBL2312411 IC50 = 2900.0 nM 5.54
CHEMBL2312415 IC50 = 4400.0 nM 5.36
CHEMBL2312414 IC50 = 4800.0 nM 5.32
CHEMBL2312427 IC50 = 5200.0 nM 5.28
CHEMBL2312426 IC50 = 7700.0 nM 5.11
CHEMBL2312433 IC50 = 9700.0 nM 5.01
CHEMBL2312429 IC50 = 9700.0 nM 5.01
CHEMBL522225 IC50 = 10100.0 nM 5.00
CHEMBL2312416 IC50 = 18000.0 nM 4.75
CHEMBL2312410 IC50 = 18600.0 nM 4.73
CHEMBL2312409 IC50 = 21800.0 nM 4.66
CHEMBL496230 IC50 = 32000.0 nM 4.50
CHEMBL2312424 IC50 - -
CHEMBL2312423 IC50 - -
CHEMBL2312422 IC50 > 300000.0 nM -
CHEMBL2312421 IC50 - -
CHEMBL2312420 IC50 - -
CHEMBL2312419 IC50 - -
CHEMBL2312418 IC50 - -
CHEMBL2312417 IC50 - -
CHEMBL2312425 IC50 - -
CHEMBL482852 IC50 - -
CHEMBL2312413 IC50 = 172000.0 nM -