Assay Detail
Functional
CHEMBL2318170
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Antitumor activity against FR-positive human KB cells assessed as decrease in cell viability measured after 48 hrs by MTT proliferation assay
4
Total Activities
4
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | KB |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of a folate-targeted rhaponticin conjugate.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 7.74 | 8.01 |
| Inhibition | 2 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2313027 | — | — | 1 | 8.01 |
| CHEMBL109266 | RHAPONTIN | — | 1 | 7.47 |
| CHEMBL2313029 | — | — | 1 | - |
| CHEMBL2313028 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2313027 | — | IC50 | = | 9.7 | nM | 8.01 |
| CHEMBL109266 | RHAPONTIN | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL2313029 | — | Inhibition | - | % | - | |
| CHEMBL2313028 | — | Inhibition | - | % | - |