Assay Detail
Binding
CHEMBL2318593
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to human PHD2 catalytic domain (181 to 426) Mn2 expressed in Escherichia coli by NMR spectroscopic analysis
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Reporter ligand NMR screening method for 2-oxoglutarate oxygenase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 6 | 6.04 | 7.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL426560 | — | — | 1 | 7.10 |
| CHEMBL2312530 | — | — | 1 | 7.00 |
| CHEMBL316034 | — | — | 1 | 6.38 |
| CHEMBL90852 | N-OXALYLGLYCINE | — | 1 | 5.52 |
| CHEMBL1230640 | — | — | 1 | 4.22 |
| CHEMBL503160 | FUMARIC ACID | 3.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL426560 | — | Kd | = | 80.0 | nM | 7.10 |
| CHEMBL2312530 | — | Kd | = | 100.0 | nM | 7.00 |
| CHEMBL316034 | — | Kd | = | 420.0 | nM | 6.38 |
| CHEMBL90852 | N-OXALYLGLYCINE | Kd | = | 3000.0 | nM | 5.52 |
| CHEMBL1230640 | — | Kd | = | 60000.0 | nM | 4.22 |
| CHEMBL503160 | FUMARIC ACID | Kd | = | 200000.0 | nM | - |