Assay Detail
Binding
CHEMBL2318645
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of HIV1 integrase strand transfer activity
42
Total Activities
42
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Human immunodeficiency virus type 1 integrase (CHEMBL3471) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Naphthyridinone (NTD) integrase inhibitors: N1 protio and methyl combination substituent effects with C3 amide groups.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 42 | 8.21 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2316125 | — | — | 1 | 8.70 |
| CHEMBL2316126 | — | — | 1 | 8.52 |
| CHEMBL2311585 | — | — | 1 | 8.52 |
| CHEMBL2316116 | — | — | 1 | 8.52 |
| CHEMBL2316127 | — | — | 1 | 8.40 |
| CHEMBL2316115 | — | — | 1 | 8.40 |
| CHEMBL2316122 | — | — | 1 | 8.40 |
| CHEMBL491347 | — | — | 1 | 8.40 |
| CHEMBL2316111 | — | — | 1 | 8.40 |
| CHEMBL2316136 | — | — | 1 | 8.40 |
| CHEMBL2316118 | — | — | 1 | 8.40 |
| CHEMBL491336 | — | — | 1 | 8.40 |
| CHEMBL522802 | — | — | 1 | 8.40 |
| CHEMBL2315831 | — | — | 1 | 8.30 |
| CHEMBL2316119 | — | — | 1 | 8.30 |
| CHEMBL2315830 | — | — | 1 | 8.30 |
| CHEMBL2315832 | — | — | 1 | 8.30 |
| CHEMBL2316120 | — | — | 1 | 8.30 |
| CHEMBL2316129 | — | — | 1 | 8.30 |
| CHEMBL492188 | — | — | 1 | 8.30 |
| CHEMBL2316132 | — | — | 1 | 8.30 |
| CHEMBL2316114 | — | — | 1 | 8.30 |
| CHEMBL2316113 | — | — | 1 | 8.30 |
| CHEMBL2316117 | — | — | 1 | 8.22 |
| CHEMBL521793 | — | — | 1 | 8.22 |
| CHEMBL2316123 | — | — | 1 | 8.22 |
| CHEMBL2316128 | — | — | 1 | 8.22 |
| CHEMBL2316137 | — | — | 1 | 8.15 |
| CHEMBL2316124 | — | — | 1 | 8.15 |
| CHEMBL2316138 | — | — | 1 | 8.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2316125 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL2316126 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL2311585 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL2316116 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL2316127 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL2316115 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL2316122 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL491347 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL2316111 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL2316136 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL2316118 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL491336 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL522802 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL2315830 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL2316119 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL2315832 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL2316120 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL2316129 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL2316132 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL2315831 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL2316114 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL2316113 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL492188 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL2316117 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL521793 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL2316123 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL2316128 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL2316137 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL2316124 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL2316121 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL1256978 | GSK-364735 | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL2316138 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL2316112 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL2316131 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL2316130 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL2316139 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL2316133 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL2315829 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL2316134 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL2315828 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL2316135 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL491538 | — | IC50 | = | 45.0 | nM | 7.35 |