Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL2318658

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of Norovirus recombinant 3CL protease using Edans-EPDFHLQGPEDLAK-Dabcyl as substrate for 30 mins by fluorometry
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Norovirus
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Inhibition of norovirus 3CL protease by bisulfite adducts of transition state inhibitors.
Mandadapu SR, Gunnam MR, Tiew KC, Uy RA, Prior AM, Alliston KR, Hua DH, Kim Y, Chang KO, Groutas WC.
Bioorg Med Chem Lett (2013) 23 : 62 -65
PubMed 23218713 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 19 5.75 6.30

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2315041 1 6.30
CHEMBL1821850 1 6.22
CHEMBL2315033 1 6.22
CHEMBL2315029 1 6.16
CHEMBL2315045 1 5.75
CHEMBL2315031 1 5.72
CHEMBL2315039 1 5.35
CHEMBL2315043 1 5.29
CHEMBL2315035 1 5.28
CHEMBL2315037 1 5.21
CHEMBL2315044 1 -
CHEMBL2315036 1 -
CHEMBL2315038 1 -
CHEMBL2315040 1 -
CHEMBL2315042 1 -
CHEMBL2315028 1 -
CHEMBL2315030 1 -
CHEMBL2315032 1 -
CHEMBL2315034 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2315041 IC50 = 500.0 nM 6.30
CHEMBL1821850 IC50 = 600.0 nM 6.22
CHEMBL2315033 IC50 = 600.0 nM 6.22
CHEMBL2315029 IC50 = 700.0 nM 6.16
CHEMBL2315045 IC50 = 1800.0 nM 5.75
CHEMBL2315031 IC50 = 1900.0 nM 5.72
CHEMBL2315039 IC50 = 4500.0 nM 5.35
CHEMBL2315043 IC50 = 5100.0 nM 5.29
CHEMBL2315035 IC50 = 5300.0 nM 5.28
CHEMBL2315037 IC50 = 6100.0 nM 5.21
CHEMBL2315044 IC50 - -
CHEMBL2315036 IC50 - -
CHEMBL2315038 IC50 - -
CHEMBL2315040 IC50 - -
CHEMBL2315042 IC50 - -
CHEMBL2315028 IC50 - -
CHEMBL2315030 IC50 - -
CHEMBL2315032 IC50 - -
CHEMBL2315034 IC50 - -