Assay Detail

CHEMBL2318753

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Binding

Inhibition of Burkholderia cenocepacia HldA assessed as ATP depletion after 30 mins by luminescence assay

ChEMBL ↗

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Target

D-beta-D-heptose 7-phosphate kinase (CHEMBL2311239) ↗

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D-beta-D-heptose 7-phosphate kinase (CHEMBL2311239) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target D-beta-D-heptose 7-phosphate kinase

CHEMBL2311239

Anchored from Assay target.

Protein identity D-beta-D-heptose 7-phosphate kinase

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Burkholderia cenocepacia
Confidence	8 — Homologous single protein target
Curated By	Autocuration

Target

D-beta-D-heptose 7-phosphate kinase (CHEMBL2311239) ↗

Type	SINGLE PROTEIN
Organism	Burkholderia cepacia (strain J2315 / LMG 16656) (Burkholderiacenocepacia (strain J2315))

Publication

Structural-functional studies of Burkholderia cenocepacia D-glycero-β-D-manno-heptose 7-phosphate kinase (HldA) and characterization of inhibitors with antibiotic adjuvant and antivirulence properties.

Lee TW, Verhey TB, Antiperovitch PA, Atamanyuk D, Desroy N, Oliveira C, Denis A, Gerusz V, Drocourt E, Loutet SA, Hamad MA, Stanetty C, Andres SN, Sugiman-Marangos S, Kosma P, Valvano MA, Moreau F, Junop MS.
J Med Chem (2013) 56 : 1405 -1417
PubMed 23256532 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	2	6.37	6.64

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL2312560	—	—	1	6.64
CHEMBL2312559	—	—	1	6.09

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL2312560	—	IC50	=	230.0	nM	6.64
CHEMBL2312559	—	IC50	=	810.0	nM	6.09