Assay Detail
Binding
CHEMBL2318866
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human sEH assessed as 6-methoxy-2-naphthaldehyde generation preincubated for 10 before addition of cyano(2-methyl-oxynaphthalen-6-yl)methyl trans-(3-phenyloxyran-2-yl) methyl carbonate by fluorescence analysis
46
Total Activities
46
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and structure-activity relationship of piperidine-derived non-urea soluble epoxide hydrolase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 46 | 7.70 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2313193 | — | — | 1 | 9.40 |
| CHEMBL2313183 | — | — | 1 | 9.22 |
| CHEMBL2313191 | — | — | 1 | 9.22 |
| CHEMBL2313190 | — | — | 1 | 8.96 |
| CHEMBL2313192 | — | — | 1 | 8.92 |
| CHEMBL2313176 | — | — | 1 | 8.80 |
| CHEMBL2313189 | — | — | 1 | 8.77 |
| CHEMBL2313181 | — | — | 1 | 8.64 |
| CHEMBL2313166 | — | — | 1 | 8.55 |
| CHEMBL2313162 | — | — | 1 | 8.34 |
| CHEMBL2313161 | — | — | 1 | 8.28 |
| CHEMBL2313186 | — | — | 1 | 8.28 |
| CHEMBL2313188 | — | — | 1 | 8.24 |
| CHEMBL2313203 | — | — | 1 | 8.22 |
| CHEMBL2313175 | — | — | 1 | 8.17 |
| CHEMBL2313167 | — | — | 1 | 8.16 |
| CHEMBL2313180 | — | — | 1 | 8.08 |
| CHEMBL2313194 | — | — | 1 | 8.07 |
| CHEMBL2313168 | — | — | 1 | 8.06 |
| CHEMBL2313173 | — | — | 1 | 7.92 |
| CHEMBL2313159 | — | — | 1 | 7.89 |
| CHEMBL2313172 | — | — | 1 | 7.77 |
| CHEMBL2313204 | — | — | 1 | 7.75 |
| CHEMBL2313169 | — | — | 1 | 7.70 |
| CHEMBL2313171 | — | — | 1 | 7.70 |
| CHEMBL2313196 | — | — | 1 | 7.70 |
| CHEMBL2313195 | — | — | 1 | 7.64 |
| CHEMBL2313182 | — | — | 1 | 7.64 |
| CHEMBL2313201 | — | — | 1 | 7.60 |
| CHEMBL2313170 | — | — | 1 | 7.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2313193 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL2313183 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL2313191 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL2313190 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL2313192 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL2313176 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL2313189 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL2313181 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL2313166 | — | IC50 | = | 2.8 | nM | 8.55 |
| CHEMBL2313162 | — | IC50 | = | 4.6 | nM | 8.34 |
| CHEMBL2313161 | — | IC50 | = | 5.2 | nM | 8.28 |
| CHEMBL2313186 | — | IC50 | = | 5.2 | nM | 8.28 |
| CHEMBL2313188 | — | IC50 | = | 5.8 | nM | 8.24 |
| CHEMBL2313203 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL2313175 | — | IC50 | = | 6.7 | nM | 8.17 |
| CHEMBL2313167 | — | IC50 | = | 6.9 | nM | 8.16 |
| CHEMBL2313180 | — | IC50 | = | 8.3 | nM | 8.08 |
| CHEMBL2313194 | — | IC50 | = | 8.5 | nM | 8.07 |
| CHEMBL2313168 | — | IC50 | = | 8.7 | nM | 8.06 |
| CHEMBL2313173 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL2313159 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL2313172 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL2313204 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL2313169 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL2313196 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL2313171 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL2313195 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL2313182 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL2313201 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL2313170 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL2313163 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL2313198 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL2313165 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL2313174 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL2313178 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL2313202 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL2313179 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL2313164 | — | IC50 | = | 102.0 | nM | 6.99 |
| CHEMBL2313160 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL2313197 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL2313187 | — | IC50 | = | 263.0 | nM | 6.58 |
| CHEMBL2313177 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL2313199 | — | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL2313200 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL2313185 | — | IC50 | = | 6900.0 | nM | 5.16 |
| CHEMBL2313184 | — | IC50 | = | 30000.0 | nM | 4.52 |