Assay Detail
Binding
CHEMBL2318921
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Inhibition of SARS coronavirus 3C-like protease R188I mutant using Dabcyl- KTSAVLQSGFRKME-Edans as substrate by fluorescence spectrophotometry
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Severe acute respiratory syndrome-related coronavirus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Design and synthesis of new tripeptide-type SARS-CoV 3CL protease inhibitors containing an electrophilic arylketone moiety.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 31 | 6.67 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2316753 | — | — | 1 | 8.52 |
| CHEMBL2316746 | — | — | 1 | 8.39 |
| CHEMBL2316751 | — | — | 1 | 7.96 |
| CHEMBL2316748 | — | — | 1 | 7.85 |
| CHEMBL2316747 | — | — | 1 | 7.66 |
| CHEMBL2316450 | — | — | 1 | 7.22 |
| CHEMBL2316457 | — | — | 1 | 6.77 |
| CHEMBL2316460 | — | — | 1 | 6.66 |
| CHEMBL2316459 | — | — | 1 | 6.66 |
| CHEMBL2316451 | — | — | 1 | 6.57 |
| CHEMBL2316458 | — | — | 1 | 6.48 |
| CHEMBL2316456 | — | — | 1 | 6.33 |
| CHEMBL2316454 | — | — | 1 | 5.89 |
| CHEMBL2316452 | — | — | 1 | 5.84 |
| CHEMBL539209 | — | — | 1 | 5.66 |
| CHEMBL2316455 | — | — | 1 | 4.66 |
| CHEMBL2316453 | — | — | 1 | 4.25 |
| CHEMBL2316741 | — | — | 1 | - |
| CHEMBL2316742 | — | — | 1 | - |
| CHEMBL2316743 | — | — | 1 | - |
| CHEMBL2316756 | — | — | 1 | - |
| CHEMBL2316465 | — | — | 1 | - |
| CHEMBL2316464 | — | — | 1 | - |
| CHEMBL2316744 | — | — | 1 | - |
| CHEMBL2316745 | — | — | 1 | - |
| CHEMBL2316749 | — | — | 1 | - |
| CHEMBL2316750 | — | — | 1 | - |
| CHEMBL2316752 | — | — | 1 | - |
| CHEMBL2316754 | — | — | 1 | - |
| CHEMBL2316755 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2316753 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL2316746 | — | Ki | = | 4.1 | nM | 8.39 |
| CHEMBL2316751 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL2316748 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL2316747 | — | Ki | = | 22.0 | nM | 7.66 |
| CHEMBL2316450 | — | Ki | = | 60.0 | nM | 7.22 |
| CHEMBL2316457 | — | Ki | = | 170.0 | nM | 6.77 |
| CHEMBL2316460 | — | Ki | = | 220.0 | nM | 6.66 |
| CHEMBL2316459 | — | Ki | = | 220.0 | nM | 6.66 |
| CHEMBL2316451 | — | Ki | = | 270.0 | nM | 6.57 |
| CHEMBL2316458 | — | Ki | = | 330.0 | nM | 6.48 |
| CHEMBL2316456 | — | Ki | = | 470.0 | nM | 6.33 |
| CHEMBL2316454 | — | Ki | = | 1300.0 | nM | 5.89 |
| CHEMBL2316452 | — | Ki | = | 1460.0 | nM | 5.84 |
| CHEMBL539209 | — | Ki | = | 2200.0 | nM | 5.66 |
| CHEMBL2316455 | — | Ki | = | 22000.0 | nM | 4.66 |
| CHEMBL2316453 | — | Ki | = | 56000.0 | nM | 4.25 |
| CHEMBL2316741 | — | Ki | - | — | - | |
| CHEMBL2316742 | — | Ki | - | — | - | |
| CHEMBL2316743 | — | Ki | - | — | - | |
| CHEMBL2316756 | — | Ki | - | — | - | |
| CHEMBL2316465 | — | Ki | - | — | - | |
| CHEMBL2316464 | — | Ki | - | — | - | |
| CHEMBL2316744 | — | Ki | - | — | - | |
| CHEMBL2316745 | — | Ki | - | — | - | |
| CHEMBL2316749 | — | Ki | - | — | - | |
| CHEMBL2316750 | — | Ki | - | — | - | |
| CHEMBL2316752 | — | Ki | - | — | - | |
| CHEMBL2316754 | — | Ki | - | — | - | |
| CHEMBL2316755 | — | Ki | - | — | - | |
| CHEMBL2316461 | — | Ki | - | — | - |