Assay Detail
Binding
CHEMBL2318922
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of SARS coronavirus 3C-like protease R188I mutant using H-TSAVLQSGFRK-NH2 as substrate after 60 mins by HPLC analysis
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Severe acute respiratory syndrome-related coronavirus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Design and synthesis of new tripeptide-type SARS-CoV 3CL protease inhibitors containing an electrophilic arylketone moiety.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 29 | 5.37 | 6.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2316752 | — | — | 1 | 6.19 |
| CHEMBL2316750 | — | — | 1 | 6.12 |
| CHEMBL2316748 | — | — | 1 | 6.04 |
| CHEMBL2316751 | — | — | 1 | 5.92 |
| CHEMBL2316460 | — | — | 1 | 5.82 |
| CHEMBL2316746 | — | — | 1 | 5.77 |
| CHEMBL2316754 | — | — | 1 | 5.77 |
| CHEMBL2316749 | — | — | 1 | 5.72 |
| CHEMBL2316747 | — | — | 1 | 5.64 |
| CHEMBL2316459 | — | — | 1 | 5.54 |
| CHEMBL2316755 | — | — | 1 | 5.47 |
| CHEMBL2316744 | — | — | 1 | 5.17 |
| CHEMBL2316461 | — | — | 1 | 5.12 |
| CHEMBL539209 | — | — | 1 | 5.02 |
| CHEMBL2316742 | — | — | 1 | 4.89 |
| CHEMBL2316745 | — | — | 1 | 4.66 |
| CHEMBL2316743 | — | — | 1 | 4.62 |
| CHEMBL2316756 | — | — | 1 | 4.44 |
| CHEMBL2316464 | — | — | 1 | 4.07 |
| CHEMBL2316753 | — | — | 1 | - |
| CHEMBL2316462 | — | — | 1 | - |
| CHEMBL2316463 | — | — | 1 | - |
| CHEMBL2316445 | — | — | 1 | - |
| CHEMBL2316446 | — | — | 1 | - |
| CHEMBL2316447 | — | — | 1 | - |
| CHEMBL2316448 | — | — | 1 | - |
| CHEMBL2316741 | — | — | 1 | - |
| CHEMBL2316465 | — | — | 1 | - |
| CHEMBL2316449 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2316752 | — | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL2316750 | — | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL2316748 | — | IC50 | = | 920.0 | nM | 6.04 |
| CHEMBL2316751 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL2316460 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL2316746 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL2316754 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL2316749 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL2316747 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL2316459 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL2316755 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL2316744 | — | IC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL2316461 | — | IC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL539209 | — | IC50 | = | 9500.0 | nM | 5.02 |
| CHEMBL2316742 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL2316745 | — | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL2316743 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL2316756 | — | IC50 | = | 36000.0 | nM | 4.44 |
| CHEMBL2316464 | — | IC50 | = | 85000.0 | nM | 4.07 |
| CHEMBL2316753 | — | IC50 | - | — | - | |
| CHEMBL2316462 | — | IC50 | > | 1600000.0 | nM | - |
| CHEMBL2316463 | — | IC50 | - | — | - | |
| CHEMBL2316445 | — | IC50 | - | — | - | |
| CHEMBL2316446 | — | IC50 | > | 1600000.0 | nM | - |
| CHEMBL2316447 | — | IC50 | = | 260000.0 | nM | - |
| CHEMBL2316448 | — | IC50 | = | 210000.0 | nM | - |
| CHEMBL2316741 | — | IC50 | = | 280000.0 | nM | - |
| CHEMBL2316465 | — | IC50 | = | 250000.0 | nM | - |
| CHEMBL2316449 | — | IC50 | > | 1600000.0 | nM | - |