Assay Detail
Binding
CHEMBL2318993
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Inhibition of human HDAC8 by fluorescence assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Histone deacetylase (HDAC) inhibitors with a novel connecting unit linker region reveal a selectivity profile for HDAC4 and HDAC5 with improved activity against chemoresistant cancer cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.14 | 6.71 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL99 | TRICHOSTATIN | 1.0 | 1 | 6.71 |
| CHEMBL2312167 | — | — | 1 | 6.08 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 6.02 |
| CHEMBL2312164 | — | — | 1 | 5.98 |
| CHEMBL2312168 | — | — | 1 | 5.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL99 | TRICHOSTATIN | IC50 | = | 196.0 | nM | 6.71 |
| CHEMBL2312167 | — | IC50 | = | 833.0 | nM | 6.08 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 960.0 | nM | 6.02 |
| CHEMBL2312164 | — | IC50 | = | 1043.0 | nM | 5.98 |
| CHEMBL2312168 | — | IC50 | = | 1278.0 | nM | 5.89 |