Assay Detail
Binding
CHEMBL2319003
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Inhibition of HDAC in cisplatin resistant human MDA-MB-231 cells after 18 hrs by fluorescence assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-231 |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Histone deacetylase (HDAC) inhibitors with a novel connecting unit linker region reveal a selectivity profile for HDAC4 and HDAC5 with improved activity against chemoresistant cancer cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.07 | 6.39 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2312168 | — | — | 1 | 6.39 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 6.21 |
| CHEMBL2312164 | — | — | 1 | 5.89 |
| CHEMBL2312167 | — | — | 1 | 5.78 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2312168 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 610.0 | nM | 6.21 |
| CHEMBL2312164 | — | IC50 | = | 1280.0 | nM | 5.89 |
| CHEMBL2312167 | — | IC50 | = | 1660.0 | nM | 5.78 |