Assay Detail
Binding
CHEMBL2319224
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to human DDR2
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Discoidin domain-containing receptor 2 (CHEMBL5122) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and biological evaluation of analogues of the kinase inhibitor nilotinib as Abl and Kit inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 4 | 7.70 | 8.25 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2311806 | — | — | 1 | 8.25 |
| CHEMBL255863 | NILOTINIB | 4.0 | 1 | 8.21 |
| CHEMBL2311807 | — | — | 1 | 7.85 |
| CHEMBL2311808 | — | — | 1 | 6.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2311806 | — | Kd | = | 5.6 | nM | 8.25 |
| CHEMBL255863 | NILOTINIB | Kd | = | 6.2 | nM | 8.21 |
| CHEMBL2311807 | — | Kd | = | 14.0 | nM | 7.85 |
| CHEMBL2311808 | — | Kd | = | 320.0 | nM | 6.50 |