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Assay Detail

CHEMBL2319334

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against human HepG2 cells measured after 48 hrs by MTT assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type HepG2
Confidence 1 — Organism
Curated By Autocuration

Target

HepG2 (CHEMBL395)
Type CELL-LINE
Organism Homo sapiens

Publication

Cytotoxic quassinoids from Ailanthus altissima.
Wang Y, Wang WJ, Su C, Zhang DM, Xu LP, He RR, Wang L, Zhang J, Zhang XQ, Ye WC.
Bioorg Med Chem Lett (2013) 23 : 654 -657
PubMed 23290052 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 15 5.87 6.72

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL53463 DOXORUBICIN 4.0 1 6.72
CHEMBL161015 AILANTHONE 1 6.62
CHEMBL2314663 ALTISSINOL A 1 6.55
CHEMBL515198 1 6.26
CHEMBL459112 1 5.94
CHEMBL472016 CHAPARRINONE 1 5.92
CHEMBL2314659 ALTISSINOL B 1 5.91
CHEMBL349383 SHINJULACTONE A 1 5.33
CHEMBL456736 1 4.98
CHEMBL3989626 GLAUCARUBIN -1.0 1 4.45
CHEMBL1723340 SHINJULACTONE B 1 -
CHEMBL2314662 SHINJULACTONE C 1 -
CHEMBL2314661 CHAPARROLIDE 1 -
CHEMBL2314660 1 -
CHEMBL345221 AMAROLIDE 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL53463 DOXORUBICIN IC50 = 190.0 nM 6.72
CHEMBL161015 AILANTHONE IC50 = 240.0 nM 6.62
CHEMBL2314663 ALTISSINOL A IC50 = 280.0 nM 6.55
CHEMBL515198 IC50 = 550.0 nM 6.26
CHEMBL459112 IC50 = 1150.0 nM 5.94
CHEMBL472016 CHAPARRINONE IC50 = 1200.0 nM 5.92
CHEMBL2314659 ALTISSINOL B IC50 = 1220.0 nM 5.91
CHEMBL349383 SHINJULACTONE A IC50 = 4670.0 nM 5.33
CHEMBL456736 IC50 = 10540.0 nM 4.98
CHEMBL3989626 GLAUCARUBIN IC50 = 35570.0 nM 4.45
CHEMBL1723340 SHINJULACTONE B IC50 > 50000.0 nM -
CHEMBL2314662 SHINJULACTONE C IC50 > 50000.0 nM -
CHEMBL2314661 CHAPARROLIDE IC50 > 50000.0 nM -
CHEMBL2314660 IC50 > 50000.0 nM -
CHEMBL345221 AMAROLIDE IC50 > 50000.0 nM -