Assay Detail
Binding
CHEMBL2319491
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Inhibition of human LCK using poly[Glu:Tyr] (4:1) peptide substrate
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of analogues of the kinase inhibitor nilotinib as Abl and Kit inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.53 | 6.97 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL255863 | NILOTINIB | 4.0 | 1 | 6.97 |
| CHEMBL2311806 | — | — | 1 | 5.84 |
| CHEMBL2311807 | — | — | 1 | 4.96 |
| CHEMBL2311808 | — | — | 1 | 4.35 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL255863 | NILOTINIB | IC50 | = | 108.2 | nM | 6.97 |
| CHEMBL2311806 | — | IC50 | = | 1448.0 | nM | 5.84 |
| CHEMBL2311807 | — | IC50 | = | 11050.0 | nM | 4.96 |
| CHEMBL2311808 | — | IC50 | = | 44620.0 | nM | 4.35 |