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Assay Detail

CHEMBL2319799

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of Influenza A virus H5N1 neuraminidase
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Influenza A virus
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Neuraminidase (CHEMBL6135)
Type SINGLE PROTEIN
Organism Influenza A virus

Publication

Structure-based design and synthesis of C-1- and C-4-modified analogs of zanamivir as neuraminidase inhibitors.
Feng E, Shin WJ, Zhu X, Li J, Ye D, Wang J, Zheng M, Zuo JP, No KT, Liu X, Zhu W, Tang W, Seong BL, Jiang H, Liu H.
J Med Chem (2013) 56 : 671 -684
PubMed 23330908 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 1 7.92 7.92

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL96712 NEU5AC2EN 1 7.92

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL96712 NEU5AC2EN IC50 = 12.0 nM 7.92