Assay Detail
Binding
CHEMBL2319887
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Inhibition of tissue factor procoagulant activity in LPS-stimulated human THP1 cells preincubated for 1 hr before LPS addition measured after 5 hrs
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | THP-1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Chemical and microbial semi-synthesis of tetrahydroprotoberberines as inhibitors on tissue factor procoagulant activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 7.24 | 8.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2314739 | — | — | 1 | 8.43 |
| CHEMBL2314733 | — | — | 1 | 8.17 |
| CHEMBL275097 | TETRAHYDROBERBERINE | — | 1 | 8.08 |
| CHEMBL2314742 | — | — | 1 | 8.06 |
| CHEMBL2314746 | — | — | 1 | 7.92 |
| CHEMBL2314744 | — | — | 1 | 7.90 |
| CHEMBL187892 | — | — | 1 | 7.82 |
| CHEMBL2314743 | — | — | 1 | 7.78 |
| CHEMBL487182 | TETRAHYDROPALMATINE | 2.0 | 1 | 7.64 |
| CHEMBL2314732 | — | — | 1 | 7.44 |
| CHEMBL2314741 | — | — | 1 | 7.41 |
| CHEMBL2314734 | — | — | 1 | 7.20 |
| CHEMBL487387 | STEPHOLIDINE | — | 1 | 6.98 |
| CHEMBL2314735 | — | — | 1 | 6.92 |
| CHEMBL448891 | — | — | 1 | 6.82 |
| CHEMBL2314745 | — | — | 1 | 6.73 |
| CHEMBL2314740 | — | — | 1 | 6.70 |
| CHEMBL140 | CURCUMIN | 3.0 | 1 | 6.70 |
| CHEMBL2314737 | — | — | 1 | 6.42 |
| CHEMBL2314738 | — | — | 1 | 6.25 |
| CHEMBL2314747 | — | — | 1 | 6.01 |
| CHEMBL2314736 | — | — | 1 | 5.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2314739 | — | IC50 | = | 3.75 | nM | 8.43 |
| CHEMBL2314733 | — | IC50 | = | 6.75 | nM | 8.17 |
| CHEMBL275097 | TETRAHYDROBERBERINE | IC50 | = | 8.35 | nM | 8.08 |
| CHEMBL2314742 | — | IC50 | = | 8.79 | nM | 8.06 |
| CHEMBL2314746 | — | IC50 | = | 12.17 | nM | 7.92 |
| CHEMBL2314744 | — | IC50 | = | 12.61 | nM | 7.90 |
| CHEMBL187892 | — | IC50 | = | 14.98 | nM | 7.82 |
| CHEMBL2314743 | — | IC50 | = | 16.8 | nM | 7.78 |
| CHEMBL487182 | TETRAHYDROPALMATINE | IC50 | = | 22.78 | nM | 7.64 |
| CHEMBL2314732 | — | IC50 | = | 36.41 | nM | 7.44 |
| CHEMBL2314741 | — | IC50 | = | 38.59 | nM | 7.41 |
| CHEMBL2314734 | — | IC50 | = | 63.06 | nM | 7.20 |
| CHEMBL487387 | STEPHOLIDINE | IC50 | = | 104.58 | nM | 6.98 |
| CHEMBL2314735 | — | IC50 | = | 118.8 | nM | 6.92 |
| CHEMBL448891 | — | IC50 | = | 152.43 | nM | 6.82 |
| CHEMBL2314745 | — | IC50 | = | 187.26 | nM | 6.73 |
| CHEMBL2314740 | — | IC50 | = | 201.93 | nM | 6.70 |
| CHEMBL140 | CURCUMIN | IC50 | = | 199.63 | nM | 6.70 |
| CHEMBL2314737 | — | IC50 | = | 376.52 | nM | 6.42 |
| CHEMBL2314738 | — | IC50 | = | 555.37 | nM | 6.25 |
| CHEMBL2314747 | — | IC50 | = | 968.9 | nM | 6.01 |
| CHEMBL2314736 | — | IC50 | = | 1501.43 | nM | 5.82 |