Assay Detail
Binding
CHEMBL2320160
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Leishmania infantum SIR2RP1
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Leishmania infantum |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Putative silent information regulator 2 (CHEMBL2311240) ↗| Type | SINGLE PROTEIN |
| Organism | Leishmania infantum |
Publication
Sirtuins as emerging anti-parasitic targets.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 4.79 | 5.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL228002 | BNIPDANON | — | 1 | 5.24 |
| CHEMBL228067 | BNIPDAOCT | — | 1 | 5.04 |
| CHEMBL508272 | SURFACTIN | — | 1 | 4.45 |
| CHEMBL1140 | NIACINAMIDE | 4.0 | 1 | 4.41 |
| CHEMBL380797 | SIRTINOL | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL228002 | BNIPDANON | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL228067 | BNIPDAOCT | IC50 | = | 9200.0 | nM | 5.04 |
| CHEMBL508272 | SURFACTIN | IC50 | = | 35200.0 | nM | 4.45 |
| CHEMBL1140 | NIACINAMIDE | IC50 | = | 39400.0 | nM | 4.41 |
| CHEMBL380797 | SIRTINOL | IC50 | = | 193800.0 | nM | - |