Assay Detail
Binding
CHEMBL2320850
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Displacement of [125I]-Tyr4-BBN from human GRPR overexpressed in human T47D cells
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | T47D |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Heterobivalent dual-target probe for targeting GRP and Y1 receptors on tumor cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 8.23 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL437027 | BOMBESIN | 1.0 | 1 | 8.70 |
| CHEMBL2314835 | — | — | 1 | 7.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL437027 | BOMBESIN | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL2314835 | — | IC50 | = | 18.0 | nM | 7.75 |