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Assay Detail

CHEMBL2321068

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of CD45 (unknown origin) expressed in Escherichia coli using pNPP substrate after 5 mins by spectrophotometric analysis
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Receptor-type tyrosine-protein phosphatase C (CHEMBL3243)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Discovery and evaluation of novel inhibitors of mycobacterium protein tyrosine phosphatase B from the 6-Hydroxy-benzofuran-5-carboxylic acid scaffold.
He Y, Xu J, Yu ZH, Gunawan AM, Wu L, Wang L, Zhang ZY.
J Med Chem (2013) 56 : 832 -842
PubMed 23305444 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 18 5.07 6.05

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2316908 1 6.05
CHEMBL2316907 1 5.44
CHEMBL2316906 1 5.39
CHEMBL2316902 1 5.38
CHEMBL2316910 1 5.26
CHEMBL2316905 1 5.05
CHEMBL2316894 1 5.00
CHEMBL2316904 1 5.00
CHEMBL2316897 1 4.94
CHEMBL2316903 1 4.89
CHEMBL2311593 1 4.88
CHEMBL2316896 1 4.85
CHEMBL2316895 1 4.72
CHEMBL2316901 1 4.10
CHEMBL2316909 1 -
CHEMBL2316898 1 -
CHEMBL2316900 1 -
CHEMBL2316899 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2316908 IC50 = 900.0 nM 6.05
CHEMBL2316907 IC50 = 3600.0 nM 5.44
CHEMBL2316906 IC50 = 4100.0 nM 5.39
CHEMBL2316902 IC50 = 4200.0 nM 5.38
CHEMBL2316910 IC50 = 5500.0 nM 5.26
CHEMBL2316905 IC50 = 9000.0 nM 5.05
CHEMBL2316894 IC50 = 10100.0 nM 5.00
CHEMBL2316904 IC50 = 10000.0 nM 5.00
CHEMBL2316897 IC50 = 11600.0 nM 4.94
CHEMBL2316903 IC50 = 13000.0 nM 4.89
CHEMBL2311593 IC50 = 13100.0 nM 4.88
CHEMBL2316896 IC50 = 14200.0 nM 4.85
CHEMBL2316895 IC50 = 18900.0 nM 4.72
CHEMBL2316901 IC50 = 80000.0 nM 4.10
CHEMBL2316909 IC50 > 100000.0 nM -
CHEMBL2316898 IC50 = 120000.0 nM -
CHEMBL2316900 IC50 > 100000.0 nM -
CHEMBL2316899 IC50 > 100000.0 nM -