Assay Detail
Functional
CHEMBL2321079
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Cytotoxicity against human NCI-H522 cells after 24 hrs by MTT assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H522 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis of amidine and bis amidine derivatives and their evaluation for anti-inflammatory and anticancer activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 4.52 | 4.87 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2311587 | — | — | 1 | 4.87 |
| CHEMBL2316315 | — | — | 1 | 4.85 |
| CHEMBL2316042 | — | — | 1 | 4.74 |
| CHEMBL2316052 | — | — | 1 | 4.66 |
| CHEMBL2316047 | — | — | 1 | 4.45 |
| CHEMBL2316050 | — | — | 1 | 4.44 |
| CHEMBL185 | FLUOROURACIL | 4.0 | 1 | 4.25 |
| CHEMBL123292 | CYCLOHEXIMIDE | 2.0 | 1 | 4.22 |
| CHEMBL88 | CYCLOPHOSPHAMIDE ANHYDROUS | 4.0 | 1 | 4.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2311587 | — | IC50 | = | 13430.0 | nM | 4.87 |
| CHEMBL2316315 | — | IC50 | = | 14050.0 | nM | 4.85 |
| CHEMBL2316042 | — | IC50 | = | 18250.0 | nM | 4.74 |
| CHEMBL2316052 | — | IC50 | = | 21980.0 | nM | 4.66 |
| CHEMBL2316047 | — | IC50 | = | 35300.0 | nM | 4.45 |
| CHEMBL2316050 | — | IC50 | = | 36620.0 | nM | 4.44 |
| CHEMBL185 | FLUOROURACIL | IC50 | = | 56760.0 | nM | 4.25 |
| CHEMBL123292 | CYCLOHEXIMIDE | IC50 | = | 60100.0 | nM | 4.22 |
| CHEMBL88 | CYCLOPHOSPHAMIDE ANHYDROUS | IC50 | = | 67900.0 | nM | 4.17 |