Assay Detail
Binding
CHEMBL2321360
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Inhibition of rat SCD1 by rat microsomal assay
54
Total Activities
54
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of liver-targeted inhibitors of stearoyl-CoA desaturase (SCD1).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 54 | 6.53 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2315179 | — | — | 1 | 9.00 |
| CHEMBL2315181 | — | — | 1 | 8.52 |
| CHEMBL2315473 | — | — | 1 | 8.52 |
| CHEMBL2315472 | — | — | 1 | 8.40 |
| CHEMBL2315480 | — | — | 1 | 8.40 |
| CHEMBL2315180 | — | — | 1 | 8.10 |
| CHEMBL2315475 | — | — | 1 | 8.00 |
| CHEMBL2315479 | — | — | 1 | 7.92 |
| CHEMBL2315498 | — | — | 1 | 7.77 |
| CHEMBL2315490 | — | — | 1 | 7.72 |
| CHEMBL2315503 | — | — | 1 | 7.50 |
| CHEMBL2315481 | — | — | 1 | 7.40 |
| CHEMBL2315497 | — | — | 1 | 7.38 |
| CHEMBL2315496 | — | — | 1 | 7.24 |
| CHEMBL2315476 | — | — | 1 | 6.89 |
| CHEMBL2315488 | — | — | 1 | 6.85 |
| CHEMBL2315486 | — | — | 1 | 6.75 |
| CHEMBL2315493 | — | — | 1 | 6.46 |
| CHEMBL2315491 | — | — | 1 | 6.42 |
| CHEMBL2315509 | — | — | 1 | 6.37 |
| CHEMBL2315483 | — | — | 1 | 6.36 |
| CHEMBL2315504 | — | — | 1 | 6.34 |
| CHEMBL2315502 | — | — | 1 | 6.17 |
| CHEMBL2315500 | — | — | 1 | 6.08 |
| CHEMBL2315477 | — | — | 1 | 6.03 |
| CHEMBL2315495 | — | — | 1 | 5.96 |
| CHEMBL2315508 | — | — | 1 | 5.92 |
| CHEMBL2315507 | — | — | 1 | 5.92 |
| CHEMBL2315513 | — | — | 1 | 5.92 |
| CHEMBL2315489 | — | — | 1 | 5.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2315179 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL2315181 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL2315473 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL2315472 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL2315480 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL2315180 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL2315475 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL2315479 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL2315498 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL2315490 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL2315503 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL2315481 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL2315497 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL2315496 | — | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL2315476 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL2315488 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL2315486 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL2315493 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL2315491 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL2315509 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL2315483 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL2315504 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL2315502 | — | IC50 | = | 680.0 | nM | 6.17 |
| CHEMBL2315500 | — | IC50 | = | 830.0 | nM | 6.08 |
| CHEMBL2315477 | — | IC50 | = | 930.0 | nM | 6.03 |
| CHEMBL2315495 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL2315507 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL2315513 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL2315508 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL2315489 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL2315517 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL2315501 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL1276654 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL2315478 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL2315485 | — | IC50 | = | 2450.0 | nM | 5.61 |
| CHEMBL2315494 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL2315510 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL2315519 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL2315482 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL2315474 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL2315484 | — | IC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL2315487 | — | IC50 | = | 8200.0 | nM | 5.09 |
| CHEMBL1683577 | — | IC50 | = | 11700.0 | nM | 4.93 |
| CHEMBL2315518 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL2315516 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2315515 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2315514 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2315506 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2315511 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2315505 | — | IC50 | > | 10000.0 | nM | - |