Assay Detail
Binding
CHEMBL2321395
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Inhibition of COX2 in human whole blood assessed as PGE2 level incubated for 15 mins prior to substrate addition measured after 10 mins by ELISA
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Tissue | Blood |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel benzoxazole inhibitors of mPGES-1.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 4.69 | 5.12 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2315853 | — | — | 1 | 5.12 |
| CHEMBL2315861 | — | — | 1 | 4.96 |
| CHEMBL2315854 | — | — | 1 | 4.56 |
| CHEMBL2315855 | — | — | 1 | 4.12 |
| CHEMBL2315856 | — | — | 1 | - |
| CHEMBL2315857 | — | — | 1 | - |
| CHEMBL2315858 | — | — | 1 | - |
| CHEMBL2315859 | — | — | 1 | - |
| CHEMBL2315860 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2315853 | — | IC50 | = | 7560.0 | nM | 5.12 |
| CHEMBL2315861 | — | IC50 | = | 11100.0 | nM | 4.96 |
| CHEMBL2315854 | — | IC50 | = | 27400.0 | nM | 4.56 |
| CHEMBL2315855 | — | IC50 | = | 76600.0 | nM | 4.12 |
| CHEMBL2315856 | — | IC50 | > | 33600.0 | nM | - |
| CHEMBL2315857 | — | IC50 | - | — | - | |
| CHEMBL2315858 | — | IC50 | - | — | - | |
| CHEMBL2315859 | — | IC50 | - | — | - | |
| CHEMBL2315860 | — | IC50 | - | — | - |