Assay Detail
Binding
CHEMBL2321397
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Inhibition of human recombinant mPGES-1 using PGH2 as substrate incubated 20 mins prior to substrate addition measured after 30 secs by EIA
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel benzoxazole inhibitors of mPGES-1.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 28 | 6.47 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL412099 | — | — | 1 | 9.00 |
| CHEMBL182032 | — | — | 1 | 8.52 |
| CHEMBL2315853 | — | — | 1 | 7.75 |
| CHEMBL2315856 | — | — | 1 | 7.47 |
| CHEMBL2315854 | — | — | 1 | 7.40 |
| CHEMBL2315857 | — | — | 1 | 7.37 |
| CHEMBL2315855 | — | — | 1 | 7.09 |
| CHEMBL2315862 | — | — | 1 | 6.75 |
| CHEMBL2315867 | — | — | 1 | 6.62 |
| CHEMBL2315866 | — | — | 1 | 6.54 |
| CHEMBL2315861 | — | — | 1 | 6.42 |
| CHEMBL2315859 | — | — | 1 | 6.11 |
| CHEMBL2315868 | — | — | 1 | 6.09 |
| CHEMBL2315864 | — | — | 1 | 6.08 |
| CHEMBL2315877 | — | — | 1 | 6.07 |
| CHEMBL2315876 | — | — | 1 | 5.92 |
| CHEMBL29097 | — | — | 1 | 5.80 |
| CHEMBL2315870 | — | — | 1 | 5.78 |
| CHEMBL2315869 | — | — | 1 | 5.52 |
| CHEMBL2315858 | — | — | 1 | 5.50 |
| CHEMBL2315865 | — | — | 1 | 5.14 |
| CHEMBL2315863 | — | — | 1 | 5.09 |
| CHEMBL2315872 | — | — | 1 | 4.89 |
| CHEMBL2315871 | — | — | 1 | - |
| CHEMBL2315874 | — | — | 1 | - |
| CHEMBL2315873 | — | — | 1 | - |
| CHEMBL2315875 | — | — | 1 | - |
| CHEMBL2315860 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL412099 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL182032 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL2315853 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL2315856 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL2315854 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL2315857 | — | IC50 | = | 43.1 | nM | 7.37 |
| CHEMBL2315855 | — | IC50 | = | 82.0 | nM | 7.09 |
| CHEMBL2315862 | — | IC50 | = | 176.0 | nM | 6.75 |
| CHEMBL2315867 | — | IC50 | = | 242.0 | nM | 6.62 |
| CHEMBL2315866 | — | IC50 | = | 291.0 | nM | 6.54 |
| CHEMBL2315861 | — | IC50 | = | 383.0 | nM | 6.42 |
| CHEMBL2315859 | — | IC50 | = | 785.0 | nM | 6.11 |
| CHEMBL2315868 | — | IC50 | = | 821.0 | nM | 6.09 |
| CHEMBL2315864 | — | IC50 | = | 826.0 | nM | 6.08 |
| CHEMBL2315877 | — | IC50 | = | 853.0 | nM | 6.07 |
| CHEMBL2315876 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL29097 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL2315870 | — | IC50 | = | 1680.0 | nM | 5.78 |
| CHEMBL2315869 | — | IC50 | = | 3010.0 | nM | 5.52 |
| CHEMBL2315858 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL2315865 | — | IC50 | = | 7180.0 | nM | 5.14 |
| CHEMBL2315863 | — | IC50 | = | 8150.0 | nM | 5.09 |
| CHEMBL2315872 | — | IC50 | = | 12900.0 | nM | 4.89 |
| CHEMBL2315871 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL2315874 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2315873 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2315875 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2315860 | — | IC50 | > | 19100.0 | nM | - |