Assay Detail
Binding
CHEMBL2327092
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Inhibition of chymotrypsin-like activity of proteasome in human NCI-H929 cells after 6 hrs by proteasomeGlo assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | NCI-H929 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Incorporation of non-natural amino acids improves cell permeability and potency of specific inhibitors of proteasome trypsin-like sites.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.21 | 5.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2326533 | — | — | 1 | 5.77 |
| CHEMBL2326260 | — | — | 1 | 5.44 |
| CHEMBL2326261 | — | — | 1 | 4.98 |
| CHEMBL2326541 | — | — | 1 | 4.98 |
| CHEMBL2326539 | — | — | 1 | 4.89 |
| CHEMBL2326272 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2326533 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL2326260 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL2326261 | — | IC50 | = | 10500.0 | nM | 4.98 |
| CHEMBL2326541 | — | IC50 | = | 10500.0 | nM | 4.98 |
| CHEMBL2326539 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL2326272 | — | IC50 | > | 30000.0 | nM | - |