Assay Detail
Binding
CHEMBL2327181
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Inhibition of JAK2 (unknown origin) after 2.5 hrs by time-resolved fluorescence resonance energy transfer assay in presence of 100 uM ATP
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design and synthesis of tricyclic cores for kinase inhibition.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.13 | 5.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2322138 | — | — | 1 | 5.24 |
| CHEMBL2159198 | — | — | 1 | 5.22 |
| CHEMBL2322139 | — | — | 1 | 4.94 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2322138 | — | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL2159198 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL2322139 | — | IC50 | = | 11400.0 | nM | 4.94 |