Assay Detail
Functional
CHEMBL2327232
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Cytotoxicity against human PC3 cells after 72 hrs by MTT assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | PC-3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of Indenopyrazoles as a New Class of Hypoxia Inducible Factor (HIF)-1 Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 4.98 | 6.14 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL432219 | — | — | 1 | 6.14 |
| CHEMBL2323950 | — | — | 1 | 5.50 |
| CHEMBL2323957 | — | — | 1 | 5.16 |
| CHEMBL371910 | — | — | 1 | 4.66 |
| CHEMBL2323951 | — | — | 1 | 4.65 |
| CHEMBL2323955 | — | — | 1 | 4.62 |
| CHEMBL2323956 | — | — | 1 | 4.59 |
| CHEMBL2323952 | — | — | 1 | 4.54 |
| CHEMBL427092 | — | — | 1 | - |
| CHEMBL333985 | — | — | 1 | - |
| CHEMBL2323954 | — | — | 1 | - |
| CHEMBL2323953 | — | — | 1 | - |
| CHEMBL371949 | — | — | 1 | - |
| CHEMBL200726 | — | — | 1 | - |
| CHEMBL175596 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL432219 | — | IC50 | = | 720.0 | nM | 6.14 |
| CHEMBL2323950 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL2323957 | — | IC50 | = | 6900.0 | nM | 5.16 |
| CHEMBL371910 | — | IC50 | = | 21700.0 | nM | 4.66 |
| CHEMBL2323951 | — | IC50 | = | 22300.0 | nM | 4.65 |
| CHEMBL2323955 | — | IC50 | = | 23700.0 | nM | 4.62 |
| CHEMBL2323956 | — | IC50 | = | 25400.0 | nM | 4.59 |
| CHEMBL2323952 | — | IC50 | = | 28800.0 | nM | 4.54 |
| CHEMBL427092 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL333985 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL2323954 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL2323953 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL371949 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL200726 | — | IC50 | < | 100.0 | nM | - |
| CHEMBL175596 | — | IC50 | > | 30000.0 | nM | - |