Assay Detail
Binding
CHEMBL2327306
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Inhibition of human recombinant NET expressed in HEK cells
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sodium-dependent noradrenaline transporter (CHEMBL222) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Azepines and piperidines with dual norepinephrine dopamine uptake inhibition and antidepressant activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 28 | 7.33 | 8.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2321991 | — | — | 1 | 8.48 |
| CHEMBL2321993 | — | — | 1 | 8.40 |
| CHEMBL51697 | — | — | 1 | 8.40 |
| CHEMBL273575 | NOMIFENSINE | 4.0 | 1 | 8.30 |
| CHEMBL2326695 | — | — | 1 | 8.29 |
| CHEMBL2326693 | — | — | 1 | 7.92 |
| CHEMBL2321996 | — | — | 1 | 7.92 |
| CHEMBL2326694 | — | — | 1 | 7.82 |
| CHEMBL2321999 | — | — | 1 | 7.77 |
| CHEMBL2322000 | — | — | 1 | 7.62 |
| CHEMBL2322001 | — | — | 1 | 7.60 |
| CHEMBL2326690 | — | — | 1 | 7.34 |
| CHEMBL2321990 | — | — | 1 | 7.31 |
| CHEMBL2321997 | — | — | 1 | 7.27 |
| CHEMBL2321995 | — | — | 1 | 7.24 |
| CHEMBL2321998 | — | — | 1 | 7.18 |
| CHEMBL2326691 | — | — | 1 | 7.13 |
| CHEMBL2322002 | — | — | 1 | 7.08 |
| CHEMBL2326689 | — | — | 1 | 6.92 |
| CHEMBL2326684 | — | — | 1 | 6.89 |
| CHEMBL2326686 | — | — | 1 | 6.89 |
| CHEMBL2326692 | — | — | 1 | 6.89 |
| CHEMBL2326685 | — | — | 1 | 6.77 |
| CHEMBL2326687 | — | — | 1 | 6.60 |
| CHEMBL2321992 | — | — | 1 | 6.60 |
| CHEMBL2326688 | — | — | 1 | 6.37 |
| CHEMBL2321994 | — | — | 1 | 6.37 |
| CHEMBL400964 | — | — | 1 | 5.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2321991 | — | Ki | = | 3.3 | nM | 8.48 |
| CHEMBL2321993 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL51697 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL273575 | NOMIFENSINE | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL2326695 | — | Ki | = | 5.1 | nM | 8.29 |
| CHEMBL2326693 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL2321996 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL2326694 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL2321999 | — | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL2322000 | — | Ki | = | 24.0 | nM | 7.62 |
| CHEMBL2322001 | — | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL2326690 | — | Ki | = | 46.0 | nM | 7.34 |
| CHEMBL2321990 | — | Ki | = | 49.0 | nM | 7.31 |
| CHEMBL2321997 | — | Ki | = | 54.0 | nM | 7.27 |
| CHEMBL2321995 | — | Ki | = | 57.0 | nM | 7.24 |
| CHEMBL2321998 | — | Ki | = | 66.0 | nM | 7.18 |
| CHEMBL2326691 | — | Ki | = | 74.0 | nM | 7.13 |
| CHEMBL2322002 | — | Ki | = | 83.0 | nM | 7.08 |
| CHEMBL2326689 | — | Ki | = | 120.0 | nM | 6.92 |
| CHEMBL2326684 | — | Ki | = | 130.0 | nM | 6.89 |
| CHEMBL2326686 | — | Ki | = | 130.0 | nM | 6.89 |
| CHEMBL2326692 | — | Ki | = | 130.0 | nM | 6.89 |
| CHEMBL2326685 | — | Ki | = | 170.0 | nM | 6.77 |
| CHEMBL2326687 | — | Ki | = | 250.0 | nM | 6.60 |
| CHEMBL2321992 | — | Ki | = | 250.0 | nM | 6.60 |
| CHEMBL2326688 | — | Ki | = | 430.0 | nM | 6.37 |
| CHEMBL2321994 | — | Ki | = | 430.0 | nM | 6.37 |
| CHEMBL400964 | — | Ki | = | 1200.0 | nM | 5.92 |