Assay Detail
Binding
CHEMBL2327339
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Inhibition of JAK2 in human UT7 cells assessed as inhibition of Epo-dependent STAT5 phosphorylation
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | UT7 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design and synthesis of tricyclic cores for kinase inhibition.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 10 | 5.39 | 6.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2322136 | — | — | 1 | 6.05 |
| CHEMBL2322137 | — | — | 1 | 5.80 |
| CHEMBL2322134 | — | — | 1 | 5.55 |
| CHEMBL2322135 | — | — | 1 | 5.38 |
| CHEMBL2322142 | — | — | 1 | 5.32 |
| CHEMBL2159198 | — | — | 1 | 5.18 |
| CHEMBL2322138 | — | — | 1 | 5.01 |
| CHEMBL2322141 | — | — | 1 | 4.80 |
| CHEMBL2322143 | — | — | 1 | - |
| CHEMBL2322139 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2322136 | — | EC50 | = | 890.0 | nM | 6.05 |
| CHEMBL2322137 | — | EC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL2322134 | — | EC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL2322135 | — | EC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL2322142 | — | EC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL2159198 | — | EC50 | = | 6600.0 | nM | 5.18 |
| CHEMBL2322138 | — | EC50 | = | 9800.0 | nM | 5.01 |
| CHEMBL2322141 | — | EC50 | = | 15800.0 | nM | 4.80 |
| CHEMBL2322143 | — | EC50 | > | 20000.0 | nM | - |
| CHEMBL2322139 | — | EC50 | > | 20000.0 | nM | - |