Assay Detail
Functional
CHEMBL2327992
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Antimalarial activity against Plasmodium falciparum D6 assessed as growth inhibition after 72 hrs by SYBR Green 1-based fluorescence assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
From a cytotoxic agent to the discovery of a novel antimalarial agent.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.21 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL172 | (S,R)-MEFLOQUINE | — | 1 | 7.70 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 7.70 |
| CHEMBL503999 | — | — | 1 | 6.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL172 | (S,R)-MEFLOQUINE | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL76 | CHLOROQUINE | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL503999 | — | IC50 | = | 600.0 | nM | 6.22 |