Assay Detail
Functional
CHEMBL2328014
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human GPR119 transfected in HEK293 cells assessed as concentration for 50 % cAMP stimulation of oleylethanolamine
9
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Glucose-dependent insulinotropic receptor (CHEMBL5652) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and biological evaluation of 5-nitropyrimidine analogs with azabicyclic substituents as GPR119 agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 9 | 8.05 | 8.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3084479 | — | — | 2 | 8.85 |
| CHEMBL3084483 | — | — | 1 | 8.82 |
| CHEMBL3084480 | — | — | 2 | 8.31 |
| CHEMBL3084481 | — | — | 1 | 8.17 |
| CHEMBL3084484 | — | — | 1 | 7.94 |
| CHEMBL280065 | OLEOYLETHANOLAMIDE | — | 1 | 5.66 |
| CHEMBL3084482 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3084479 | — | EC50 | = | 1.4 | nM | 8.85 |
| CHEMBL3084479 | — | EC50 | = | 1.5 | nM | 8.82 |
| CHEMBL3084483 | — | EC50 | = | 1.5 | nM | 8.82 |
| CHEMBL3084480 | — | EC50 | = | 4.9 | nM | 8.31 |
| CHEMBL3084481 | — | EC50 | = | 6.7 | nM | 8.17 |
| CHEMBL3084484 | — | EC50 | = | 11.5 | nM | 7.94 |
| CHEMBL3084480 | — | EC50 | = | 14.5 | nM | 7.84 |
| CHEMBL280065 | OLEOYLETHANOLAMIDE | EC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL3084482 | — | EC50 | > | 10000.0 | nM | - |