Assay Detail
Binding
CHEMBL2328061
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Inhibition of human beta-casein/Tcf4 interaction after 1 hr by fluorescence polarization assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
High-Throughput Selectivity Assays for Small-Molecule Inhibitors of β-Catenin/T-Cell Factor Protein-Protein Interactions.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 4.84 | 5.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2323032 | — | — | 1 | 5.51 |
| CHEMBL578512 | — | — | 1 | 5.24 |
| CHEMBL2323029 | — | — | 1 | 5.06 |
| CHEMBL2323031 | — | — | 1 | 4.80 |
| CHEMBL460433 | CALPHOSTIN C | — | 1 | 4.75 |
| CHEMBL2323033 | — | — | 1 | 4.44 |
| CHEMBL2323028 | — | — | 1 | 4.11 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2323032 | — | Ki | = | 3100.0 | nM | 5.51 |
| CHEMBL578512 | — | Ki | = | 5800.0 | nM | 5.24 |
| CHEMBL2323029 | — | Ki | = | 8800.0 | nM | 5.06 |
| CHEMBL2323031 | — | Ki | = | 16000.0 | nM | 4.80 |
| CHEMBL460433 | CALPHOSTIN C | Ki | = | 18000.0 | nM | 4.75 |
| CHEMBL2323033 | — | Ki | = | 36000.0 | nM | 4.44 |
| CHEMBL2323028 | — | Ki | = | 77000.0 | nM | 4.11 |