Assay Detail
Functional
CHEMBL2328196
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Cytotoxicity against human PANC1 cells after 72 hrs by MTS assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | PANC-1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of O-Alkylamino Tethered Niclosamide Derivatives as Potent and Orally Bioavailable Anticancer Agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 5.77 | 6.27 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2326742 | — | — | 1 | 6.27 |
| CHEMBL2326743 | — | — | 1 | 5.97 |
| CHEMBL1448 | NICLOSAMIDE | 4.0 | 1 | 5.76 |
| CHEMBL2326727 | — | — | 1 | 5.51 |
| CHEMBL2326729 | — | — | 1 | 5.33 |
| CHEMBL2326732 | — | — | 1 | - |
| CHEMBL2326731 | — | — | 1 | - |
| CHEMBL2326730 | — | — | 1 | - |
| CHEMBL2326728 | — | — | 1 | - |
| CHEMBL2326741 | — | — | 1 | - |
| CHEMBL2326740 | — | — | 1 | - |
| CHEMBL2326739 | — | — | 1 | - |
| CHEMBL2326738 | — | — | 1 | - |
| CHEMBL2326737 | — | — | 1 | - |
| CHEMBL2326736 | — | — | 1 | - |
| CHEMBL2326735 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2326742 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL2326743 | — | IC50 | = | 1080.0 | nM | 5.97 |
| CHEMBL1448 | NICLOSAMIDE | IC50 | = | 1730.0 | nM | 5.76 |
| CHEMBL2326727 | — | IC50 | = | 3110.0 | nM | 5.51 |
| CHEMBL2326729 | — | IC50 | = | 4670.0 | nM | 5.33 |
| CHEMBL2326732 | — | IC50 | - | — | - | |
| CHEMBL2326731 | — | IC50 | - | — | - | |
| CHEMBL2326730 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2326728 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2326741 | — | IC50 | - | — | - | |
| CHEMBL2326740 | — | IC50 | - | — | - | |
| CHEMBL2326739 | — | IC50 | - | — | - | |
| CHEMBL2326738 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2326737 | — | IC50 | - | — | - | |
| CHEMBL2326736 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2326735 | — | IC50 | - | — | - |