Assay Detail
Binding
CHEMBL2328240
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Inhibition of human CA9 by stopped-flow assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel small molecule protein arginine deiminase 4 (PAD4) inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 6.22 | 7.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 7.60 |
| CHEMBL2323125 | — | — | 1 | 7.47 |
| CHEMBL20767 | 4-GUANIDINO-BENZOIC ACID | — | 1 | 5.59 |
| CHEMBL2323124 | — | — | 1 | 5.38 |
| CHEMBL14060 | PHENOL | 4.0 | 1 | 5.06 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL2323125 | — | Ki | = | 34.0 | nM | 7.47 |
| CHEMBL20767 | 4-GUANIDINO-BENZOIC ACID | Ki | = | 2560.0 | nM | 5.59 |
| CHEMBL2323124 | — | Ki | = | 4130.0 | nM | 5.38 |
| CHEMBL14060 | PHENOL | Ki | = | 8800.0 | nM | 5.06 |