Assay Detail
Binding
CHEMBL2328333
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Binding affinity to Bcl-2 (unknown origin) by surface plasmon resonance analysis
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
The role of the acidity of N-heteroaryl sulfonamides as inhibitors of bcl-2 family protein-protein interactions.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 10 | 8.16 | 9.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL376408 | ABT 737 | 1.0 | 1 | 9.22 |
| CHEMBL2326747 | — | — | 1 | 8.70 |
| CHEMBL2326746 | — | — | 1 | 8.52 |
| CHEMBL2326744 | — | — | 1 | 8.30 |
| CHEMBL2326745 | — | — | 1 | 8.15 |
| CHEMBL2322026 | — | — | 1 | 8.10 |
| CHEMBL2322022 | — | — | 1 | 8.00 |
| CHEMBL2322027 | — | — | 1 | 7.85 |
| CHEMBL2322021 | — | — | 1 | 7.77 |
| CHEMBL2322020 | — | — | 1 | 6.98 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL376408 | ABT 737 | Kd | = | 0.6 | nM | 9.22 |
| CHEMBL2326747 | — | Kd | = | 2.0 | nM | 8.70 |
| CHEMBL2326746 | — | Kd | = | 3.0 | nM | 8.52 |
| CHEMBL2326744 | — | Kd | = | 5.0 | nM | 8.30 |
| CHEMBL2326745 | — | Kd | = | 7.0 | nM | 8.15 |
| CHEMBL2322026 | — | Kd | = | 8.0 | nM | 8.10 |
| CHEMBL2322022 | — | Kd | = | 10.0 | nM | 8.00 |
| CHEMBL2322027 | — | Kd | = | 14.0 | nM | 7.85 |
| CHEMBL2322021 | — | Kd | = | 17.0 | nM | 7.77 |
| CHEMBL2322020 | — | Kd | = | 104.0 | nM | 6.98 |