Assay Detail
Functional
CHEMBL2328338
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Inhibition of cell migration in human MDA-MB-231 cells assessed as total number of cells after 24 hrs by transwell migration assay
11
Total Activities
10
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-231 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of a Series of Thiazole Derivatives as Novel Inhibitors of Metastatic Cancer Cell Migration and Invasion.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.07 | 6.75 |
| Inhibition | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2322050 | — | — | 2 | 6.75 |
| CHEMBL2322049 | — | — | 1 | 6.72 |
| CHEMBL2322034 | — | — | 1 | 6.44 |
| CHEMBL471411 | — | — | 1 | 6.08 |
| CHEMBL2322057 | — | — | 1 | 6.00 |
| CHEMBL2322042 | — | — | 1 | 5.95 |
| CHEMBL60334 | — | — | 1 | 5.89 |
| CHEMBL2322048 | — | — | 1 | 5.68 |
| CHEMBL1462011 | — | — | 1 | 5.60 |
| CHEMBL482012 | — | — | 1 | 5.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2322050 | — | IC50 | = | 176.0 | nM | 6.75 |
| CHEMBL2322049 | — | IC50 | = | 189.0 | nM | 6.72 |
| CHEMBL2322034 | — | IC50 | = | 366.0 | nM | 6.44 |
| CHEMBL471411 | — | IC50 | = | 839.0 | nM | 6.08 |
| CHEMBL2322057 | — | IC50 | = | 1010.0 | nM | 6.00 |
| CHEMBL2322042 | — | IC50 | = | 1120.0 | nM | 5.95 |
| CHEMBL60334 | — | IC50 | = | 1290.0 | nM | 5.89 |
| CHEMBL2322048 | — | IC50 | = | 2080.0 | nM | 5.68 |
| CHEMBL1462011 | — | IC50 | = | 2490.0 | nM | 5.60 |
| CHEMBL482012 | — | IC50 | = | 2870.0 | nM | 5.54 |
| CHEMBL2322050 | — | Inhibition | - | % | - |