Assay Detail
Binding
CHEMBL2328840
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Inhibition of Mycobacterium tuberculosis Rv1284 beta-carbonic anhydrase by stopped flow assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mycobacterium tuberculosis |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Inhibition of the β-carbonic anhydrases from Mycobacterium tuberculosis with C-cinnamoyl glycosides: identification of the first inhibitor with anti-mycobacterial activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 5.59 | 6.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2323138 | — | — | 1 | 6.85 |
| CHEMBL550572 | — | — | 1 | 6.03 |
| CHEMBL2323139 | — | — | 1 | 5.94 |
| CHEMBL2323134 | — | — | 1 | 5.68 |
| CHEMBL2323135 | — | — | 1 | 5.54 |
| CHEMBL2323136 | — | — | 1 | 5.42 |
| CHEMBL2323140 | — | — | 1 | 5.35 |
| CHEMBL2323137 | — | — | 1 | 5.35 |
| CHEMBL14060 | PHENOL | 4.0 | 1 | 4.19 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2323138 | — | Ki | = | 140.0 | nM | 6.85 |
| CHEMBL550572 | — | Ki | = | 930.0 | nM | 6.03 |
| CHEMBL2323139 | — | Ki | = | 1160.0 | nM | 5.94 |
| CHEMBL2323134 | — | Ki | = | 2100.0 | nM | 5.68 |
| CHEMBL2323135 | — | Ki | = | 2900.0 | nM | 5.54 |
| CHEMBL2323136 | — | Ki | = | 3800.0 | nM | 5.42 |
| CHEMBL2323140 | — | Ki | = | 4500.0 | nM | 5.35 |
| CHEMBL2323137 | — | Ki | = | 4500.0 | nM | 5.35 |
| CHEMBL14060 | PHENOL | Ki | = | 64000.0 | nM | 4.19 |