Assay Detail
Functional
CHEMBL2328880
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Antimalarial activity against Plasmodium falciparum 3D7 assessed as inhibition of parasite growth
49
Total Activities
49
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Novel diaryl ureas with efficacy in a mouse model of malaria.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 47 | 5.55 | 7.43 |
| XC50 | 2 | 6.38 | 6.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2325355 | — | — | 1 | 7.43 |
| CHEMBL2325358 | — | — | 1 | 7.14 |
| CHEMBL2325374 | — | — | 1 | 7.09 |
| CHEMBL2325360 | — | — | 1 | 6.89 |
| CHEMBL2325356 | — | — | 1 | 6.89 |
| CHEMBL2325357 | — | — | 1 | 6.75 |
| CHEMBL532695 | — | — | 1 | 6.72 |
| CHEMBL2325375 | — | — | 1 | 6.70 |
| CHEMBL2325352 | — | — | 1 | 6.21 |
| CHEMBL2325393 | — | — | 1 | 6.14 |
| CHEMBL532334 | — | — | 1 | 6.03 |
| CHEMBL2325394 | — | — | 1 | 5.92 |
| CHEMBL2325359 | — | — | 1 | 5.82 |
| CHEMBL2325354 | — | — | 1 | 5.72 |
| CHEMBL2325353 | — | — | 1 | 5.70 |
| CHEMBL2325386 | — | — | 1 | 5.64 |
| CHEMBL849 | TRICLOSAN | 4.0 | 1 | 5.54 |
| CHEMBL2325389 | — | — | 1 | 5.33 |
| CHEMBL2325387 | — | — | 1 | 5.14 |
| CHEMBL2325391 | — | — | 1 | 5.01 |
| CHEMBL2325392 | — | — | 1 | 4.75 |
| CHEMBL2325382 | — | — | 1 | 4.70 |
| CHEMBL2325390 | — | — | 1 | 4.48 |
| CHEMBL2325388 | — | — | 1 | 4.42 |
| CHEMBL2325385 | — | — | 1 | 4.28 |
| CHEMBL2325384 | — | — | 1 | 4.14 |
| CHEMBL198782 | — | — | 1 | 4.00 |
| CHEMBL198831 | — | — | 1 | 4.00 |
| CHEMBL2325395 | — | — | 1 | 4.00 |
| CHEMBL2325380 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2325355 | — | EC50 | = | 37.0 | nM | 7.43 |
| CHEMBL2325358 | — | EC50 | = | 72.0 | nM | 7.14 |
| CHEMBL2325374 | — | EC50 | = | 81.0 | nM | 7.09 |
| CHEMBL2325360 | — | EC50 | = | 130.0 | nM | 6.89 |
| CHEMBL2325356 | — | EC50 | = | 130.0 | nM | 6.89 |
| CHEMBL2325357 | — | EC50 | = | 180.0 | nM | 6.75 |
| CHEMBL532695 | — | XC50 | = | 190.0 | nM | 6.72 |
| CHEMBL2325375 | — | EC50 | = | 200.0 | nM | 6.70 |
| CHEMBL2325352 | — | EC50 | = | 610.0 | nM | 6.21 |
| CHEMBL2325393 | — | EC50 | = | 730.0 | nM | 6.14 |
| CHEMBL532334 | — | XC50 | = | 930.0 | nM | 6.03 |
| CHEMBL2325394 | — | EC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL2325359 | — | EC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL2325354 | — | EC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL2325353 | — | EC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL2325386 | — | EC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL849 | TRICLOSAN | EC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL2325389 | — | EC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL2325387 | — | EC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL2325391 | — | EC50 | = | 9700.0 | nM | 5.01 |
| CHEMBL2325392 | — | EC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL2325382 | — | EC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL2325390 | — | EC50 | = | 33000.0 | nM | 4.48 |
| CHEMBL2325388 | — | EC50 | = | 38000.0 | nM | 4.42 |
| CHEMBL2325385 | — | EC50 | = | 52000.0 | nM | 4.28 |
| CHEMBL2325384 | — | EC50 | = | 73000.0 | nM | 4.14 |
| CHEMBL198782 | — | EC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL198831 | — | EC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL2325395 | — | EC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL2325363 | — | EC50 | = | 0.5 | ug.mL-1 | - |
| CHEMBL2325364 | — | EC50 | = | 1.3 | ug.mL-1 | - |
| CHEMBL2325365 | — | EC50 | = | 2.3 | ug.mL-1 | - |
| CHEMBL2325361 | — | EC50 | = | 0.29 | ug.mL-1 | - |
| CHEMBL2325383 | — | EC50 | > | 150000.0 | nM | - |
| CHEMBL2325377 | — | EC50 | = | 0.047 | ug.mL-1 | - |
| CHEMBL2325371 | — | EC50 | = | 0.077 | ug.mL-1 | - |
| CHEMBL2325379 | — | EC50 | = | 1.1 | ug.mL-1 | - |
| CHEMBL2325372 | — | EC50 | = | 0.3 | ug.mL-1 | - |
| CHEMBL2325370 | — | EC50 | = | 0.3 | ug.mL-1 | - |
| CHEMBL2325369 | — | EC50 | = | 0.14 | ug.mL-1 | - |
| CHEMBL2325376 | — | EC50 | = | 0.037 | ug.mL-1 | - |
| CHEMBL2325368 | — | EC50 | = | 0.14 | ug.mL-1 | - |
| CHEMBL2325378 | — | EC50 | = | 1.8 | ug.mL-1 | - |
| CHEMBL2325362 | — | EC50 | = | 0.6 | ug.mL-1 | - |
| CHEMBL2325367 | — | EC50 | = | 0.6 | ug.mL-1 | - |
| CHEMBL2325366 | — | EC50 | = | 0.8 | ug.mL-1 | - |
| CHEMBL2325381 | — | EC50 | = | 1.4 | ug.mL-1 | - |
| CHEMBL2325373 | — | EC50 | = | 3.9 | ug.mL-1 | - |
| CHEMBL2325380 | — | EC50 | = | 0.6 | ug.mL-1 | - |