Assay Detail
Functional
CHEMBL2328955
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HCV1b infected in human HuH7 cells assessed as inhibition of viral RNA replication after 72 hrs by luciferase reporter gene assay
19
Total Activities
19
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Hepacivirus hominis |
| Cell Type | Huh-7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Imidazopyridine-Based Fatty Acid Synthase Inhibitors That Show Anti-HCV Activity and in Vivo Target Modulation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 13 | 6.81 | 7.75 |
| IC50 | 6 | 5.48 | 6.29 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2322360 | — | — | 1 | 7.75 |
| CHEMBL2322370 | — | — | 1 | 7.40 |
| CHEMBL2322359 | — | — | 1 | 7.08 |
| CHEMBL2322361 | — | — | 1 | 7.04 |
| CHEMBL2322363 | — | — | 1 | 6.89 |
| CHEMBL2322374 | — | — | 1 | 6.82 |
| CHEMBL2322371 | — | — | 1 | 6.76 |
| CHEMBL2322364 | — | — | 1 | 6.51 |
| CHEMBL2322365 | — | — | 1 | 6.29 |
| CHEMBL2322368 | — | — | 1 | 6.28 |
| CHEMBL2322372 | — | — | 1 | 6.26 |
| CHEMBL2322367 | — | — | 1 | 6.08 |
| CHEMBL2322362 | — | — | 1 | 5.61 |
| CHEMBL2322369 | — | — | 1 | 5.51 |
| CHEMBL2322366 | — | — | 1 | 4.51 |
| CHEMBL2322375 | — | — | 1 | - |
| CHEMBL2322373 | — | — | 1 | - |
| CHEMBL2322376 | — | — | 1 | - |
| CHEMBL2322659 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2322360 | — | EC50 | = | 18.0 | nM | 7.75 |
| CHEMBL2322370 | — | EC50 | = | 40.0 | nM | 7.40 |
| CHEMBL2322359 | — | EC50 | = | 84.0 | nM | 7.08 |
| CHEMBL2322361 | — | EC50 | = | 91.0 | nM | 7.04 |
| CHEMBL2322363 | — | EC50 | = | 130.0 | nM | 6.89 |
| CHEMBL2322374 | — | EC50 | = | 150.0 | nM | 6.82 |
| CHEMBL2322371 | — | EC50 | = | 175.0 | nM | 6.76 |
| CHEMBL2322364 | — | EC50 | = | 310.0 | nM | 6.51 |
| CHEMBL2322365 | — | IC50 | = | 510.0 | nM | 6.29 |
| CHEMBL2322368 | — | EC50 | = | 520.0 | nM | 6.28 |
| CHEMBL2322372 | — | EC50 | = | 550.0 | nM | 6.26 |
| CHEMBL2322367 | — | EC50 | = | 830.0 | nM | 6.08 |
| CHEMBL2322362 | — | IC50 | = | 2430.0 | nM | 5.61 |
| CHEMBL2322369 | — | IC50 | = | 3070.0 | nM | 5.51 |
| CHEMBL2322366 | — | IC50 | = | 31000.0 | nM | 4.51 |
| CHEMBL2322375 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL2322373 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL2322376 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL2322659 | — | IC50 | > | 50000.0 | nM | - |