Assay Detail
Binding
CHEMBL2329040
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of JAK1/JAK2/TYK2 in human PBMC expressing CD14 assessed as inhibition of IL-6-stimulated STAT3 phosphorylation after 30 mins by flow cytometric analysis
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
3-Amido pyrrolopyrazine JAK kinase inhibitors: development of a JAK3 vs JAK1 selective inhibitor and evaluation in cellular and in vivo models.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.48 | 6.76 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2325898 | — | — | 1 | 6.76 |
| CHEMBL221959 | TOFACITINIB | 4.0 | 1 | 6.62 |
| CHEMBL2325895 | — | — | 1 | 6.06 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2325898 | — | IC50 | = | 175.0 | nM | 6.76 |
| CHEMBL221959 | TOFACITINIB | IC50 | = | 238.0 | nM | 6.62 |
| CHEMBL2325895 | — | IC50 | = | 864.0 | nM | 6.06 |